BMJ:偏头痛患者手术发生缺血性卒中和再入院风险更大

2017-01-11 xing.T MedSci原创

有偏头痛的手术患者发生围手术期缺血性卒中的风险增加,并且增加了30天内的再入院率。在围手术期缺血性卒中的风险评估中应考虑偏头痛这一因素。

最近,顶级医学期刊 BMJ 上发表了一篇研究文章,研究人员旨在探讨偏头痛患者在围手术期缺血性中风的风险是否会增加,并且这是否会导致再住院率增加。

该研究作为一项前瞻性研究,在2007年1月至2014年8月期间,研究者以马萨诸塞总医院及两座下属校区为基础,共纳入了124,558名进行外科手术的患者作为参与者(平均年龄52.6岁;女性占54.5%)。主要结局指标为无偏头痛先兆和有偏头痛先兆的患者术后30天内发生的围手术期缺血性卒中;次要结局指标为术后30天内再住院情况;探索性结局包括出院后卒中和卒中部位的神经解剖学层次。

研究者发现共有10,179(8.2%)名患者诊断有偏头痛,其中1278(12.6%)名患者为有先兆偏头痛,8901(87.4%)名患者为无先兆偏头痛。771(0.6%)名患者在术后30天内发生围手术期缺血性卒中。


与无偏头痛患者相比,偏头痛患者围术期缺血性卒中风险明显增加(调整后的比值比为1.75,95%可信区间为1.39-2.21)。有先兆偏头痛患者的风险(调整后比值比为2.61,1.59-4.29)也高于无先兆偏头痛患者(1.62,1.26-2.09)。

每1000个手术患者发生围手术期缺血性卒中预测的绝对风险为2.4(2.1-2.8)。而每1000例偏头痛患者预测的绝对风险增加到4.3(3.2-5.3),无先兆偏头痛患者预测的绝对风险为3.9(2.9-5),有先兆偏头痛患者预测的绝对风险为6.3(3.2-9.5),偏头痛患者在出院30天内有较高的再入院率(调整后的比值比为1.31,1.22-1.41)。

有偏头痛的手术患者发生围手术期缺血性卒中的风险增加,并且增加了30天内的再入院率。在围手术期缺血性卒中的风险评估中应考虑偏头痛这一因素。

原始出处:

Fanny P Timm, et al. Migraine and risk of perioperative ischemic stroke and hospital readmission: hospital based registry study. BMJ.10 January 2017.

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    2017-01-18 gaoxiaoe
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    2017-01-12 susice

    该怎样预防

    0

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    2017-01-11 虈亣靌

    学习一下,对自己有帮助

    0