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BMJ：UK Biobank 研究模式对结论的影响

2020-02-15 MedSci MedSci原创

UKBiobank心血管风险因素参与者应答率
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研究认为，虽然UK Biobank研究参与者应答率低，但研究结果与传统队列研究基本一致

近日研究人员将UK Biobank研究与其他代表性研究相比较，考察了不同研究模式对心血管风险因素及死亡率的结论差异。

研究人员分析了499701例UK Biobank队列参与者（参与者应答率为5.5%），以HSE和SHS数据库中的18个研究为对照（包含89895名参与者，平均应答率为68%）。研究的主要终点为心血管疾病、肿瘤以及自杀死亡。

相比于传统队列研究，UK Biobank研究模式覆盖范围广，但参与者研究应答率低，二者风险因素与死亡率的相关性保持一致。7年UK Biobank研究中，总计记录14288例患者死亡，而HSE-SHS研究10年记录7861例患者死亡，在调整年龄及性别后，UK Biobank研究发现吸烟史人群的心血管死亡风险为2.04，而HSE-SHS队列为1.99，二者研究结论基本一致。

研究认为，虽然UK Biobank研究参与者应答率低，但研究结果与传统队列研究基本一致。

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    2023-12-01 侠胆医心 来自威斯康星

    虽然#UK biobank#研究参与者应答率低，但研究结果与传统#队列研究#基本一致。可能主要原因在于样本量巨大，可以消除很多#偏倚#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2172243, encodeId=899521e224305, content=虽然<a href='/topic/show?id=43ed1080e969' target=_blank style='color:#2F92EE;'>#UK biobank#</a>研究参与者应答率低，但研究结果与传统<a href='/topic/show?id=fdef9e3606b' target=_blank style='color:#2F92EE;'>#队列研究#</a>基本一致。可能主要原因在于样本量巨大，可以消除很多<a href='/topic/show?id=18cb2e6060d' target=_blank style='color:#2F92EE;'>#偏倚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27606, encryptionId=18cb2e6060d, topicName=偏倚), TopicDto(id=97360, encryptionId=fdef9e3606b, topicName=队列研究), TopicDto(id=108079, encryptionId=43ed1080e969, topicName=UK biobank)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Dec 01 04:06:34 CST 2023, time=2023-12-01, status=1, ipAttribution=威斯康星), GetPortalCommentsPageByObjectIdResponse(id=1848955, encodeId=3425184895577, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Sep 26 12:06:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918977, encodeId=5bf719189e7c6, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 28 16:06:00 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-09-26 gaoxiaoe

    #BMJ#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2172243, encodeId=899521e224305, content=虽然<a href='/topic/show?id=43ed1080e969' target=_blank style='color:#2F92EE;'>#UK biobank#</a>研究参与者应答率低，但研究结果与传统<a href='/topic/show?id=fdef9e3606b' target=_blank style='color:#2F92EE;'>#队列研究#</a>基本一致。可能主要原因在于样本量巨大，可以消除很多<a href='/topic/show?id=18cb2e6060d' target=_blank style='color:#2F92EE;'>#偏倚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27606, encryptionId=18cb2e6060d, topicName=偏倚), TopicDto(id=97360, encryptionId=fdef9e3606b, topicName=队列研究), TopicDto(id=108079, encryptionId=43ed1080e969, topicName=UK biobank)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Fri Dec 01 04:06:34 CST 2023, time=2023-12-01, status=1, ipAttribution=威斯康星), GetPortalCommentsPageByObjectIdResponse(id=1848955, encodeId=3425184895577, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Sep 26 12:06:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918977, encodeId=5bf719189e7c6, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 28 16:06:00 CST 2020, time=2020-12-28, status=1, ipAttribution=)]
    2020-12-28 sunylz

    #Bio#

    0