Lancet：母亲妊娠期维生素D水平不影响子代骨矿物质含量

　　英国一项前瞻性队列研究纳入3960对母-子（女），其中子代的平均年龄为9.9岁，受试女性在妊娠期间的血清25羟维生素D水平充足、不足或缺乏者分别为2644（77%）、1096（28%）和220（6%）名。与血清25羟维生素D水平充足女性的子代相比，另两组女性子代的全身（不含头部，TBLH）和脊柱骨矿物质含量（BMC）并无差异。女性妊娠全程（包括妊娠晚期在内）的血清25羟维生素D与子代的BMC均无相关性。论文3月19日在线发表于《柳叶刀》（Lancet）杂志。

与维生素D相关的拓展阅读：

• 上海女性缺乏维生素D 或与乳腺癌高发相关
• PlOS Med:肥胖导致人体内维生素D不足
• Eur Heart J：25-羟维生素D水平与严重心脑血管事件相关
• JAMA:补充维生素D 对膝关节骨性关节炎症状无益
• J Clin Endocrinol Metab：孕期维生素D水平影响胎儿发育
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Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study

Background

Maternal vitamin D status in pregnancy is a suggested determinant of bone-mineral content (BMC) in offspring, but has been assessed in small studies. We investigated this association in a large prospective study.

Methods

Eligible participants were mother-and-singleton-offspring pairs who had participated in the Avon Longitudinal Study of Parents and Children, and in which the mother had recorded measurements of 25(OH)D concentration in pregnancy and the offspring had undergone dual-energy x-ray absorptiometry at age 9—10 years. 25(OH)D concentrations in pregnancy were assessed per 10·0 nmol/L and classified as sufficient (more than 50·00 nmol/L), insufficient (49·99—27·50 nmol/L), or deficient (lower than 27·50 nmol/L). Associations between maternal serum 25(OH)D concentrations and offspring total body less head (TBLH) and spinal BMC were assessed by trimester.

Results

3960 mother-and-offspring pairs, mainly of white European origin, were assessed (TBLH BMC n=3960, spinal BMC n=3196). Mean offspring age was 9·9 years. 2644 (77%) mothers had sufficient, 1096 (28%) insufficient, and 220 (6%) deficient 25(OH)D concentrations in pregnancy, but TBLH and spinal BMC did not differ between offspring of mothers in the lower two groups versus sufficient 25(OH)D concentration. No associations with offspring BMC were found for any trimester, including the third trimester, which is thought to be most relevant (TBLH BMC confounder-adjusted mean difference −0·03 g per 10·0 nmol/L, 95% CI −1·71 to 1·65; spinal BMC 0·04 g per 10·0 nmol/L, 95% CI −0·12 to 0·21).

Conclusions

We found no relevant association between maternal vitamin D status in pregnancy and offspring BMC in late childhood.

Funding

UK Medical Research Council, Wellcome Trust, and University of Bristol.