KIDNEY INT:先天性心脏病患者的心脏手术与急性肾损伤和慢性肾脏病风险相关!

2017-04-16 xing.T MedSci原创

因此,先天性心脏病患者发生CS-AKI是常见的,与发生CKD的风险增加有关。

在30-50%的先天性心脏病手术的患者中会发生心脏手术相关的急性肾损伤(CS-AKI)。近日,肾脏病领域权威杂志kidney international上发表了一篇研究文章,在这项研究中,研究人员旨在明确CS-AKI是否与先天性心脏病患者的慢性肾脏疾病(CKD)相关。

研究人员利用丹麦区域人口为基础的登记中心,研究人员的队列研究纳入了出生于1990-2010年期间并在2005-2010年期间(15岁以下)进行首次心脏手术的先天性心脏病患者。利用在门诊和住院实验室血清肌酐的数据,研究人员确定了心脏手术后5天内患者符合AKI 的KDIGO阶段。研究人员使用独特的个人标识符能够明确数据链接,并且几乎得到全部随访数据。

研究人员利用血清肌酐值和pottel的公式根据存在CS-AKI计算了2-5期CKD的累计发生率。使用Cox回归分析,计算了相应的风险比,调整了性别、首次心脏手术的年龄、手术日期和先天性心脏疾病的严重程度。382例接受心脏手术的先天性心脏病患者,127例患者在心脏手术5天内发生了CS-AKI。中位随访时间为4.9年。CS-AKI患者CKD的五年累计发生率为12%(95%可信区间为7%-20%),明显高于那些没有CS-AKI患者的3%(1%-5%),其显著的调整后风险比为3.8(1.4-10.4)。

因此,先天性心脏病患者发生CS-AKI是常见的,与发生CKD的风险增加有关。

原始出处:


Nicolas L. Madsen,et al. Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease.kidney-international.2017. http://www.kidney-international.org/article/S0085-2538(17)30155-2/fulltext

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    2017-04-26 1ddf0692m34(暂无匿称)

    学习了,很好

    0

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    2017-04-19 大爰

    天天学习,

    0

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    2017-04-18 huirong
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    2017-04-18 gwc389
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    2017-04-16 虈亣靌

    非常好的文章,学习了

    0