J Investig Clin Dent:牙釉质凝胶在牙齿漂白后大鼠牙髓组织中的抗炎作用

2019-02-07 MedSci MedSci原创

卡维地洛是一种减少牙周炎炎症的抗氧化剂。漂白凝胶的过氧化氢(H 2 O 2)引起牙髓的炎症和坏死。在本研究中,我们评估了卡维地洛在漂白后大鼠牙髓中的抗炎作用。大鼠右上臼齿接受35%H2O2(1×30分钟),左上臼齿作为对照。一半大鼠接受卡维地洛凝胶(1×10分钟),形成以下组:漂白,漂白,然后用卡维地洛(漂白+卡维地洛)和对照。在第2天和第30天(N = 7个半上颌/组)后,杀死大鼠进行组织学评估

卡维地洛是一种减少牙周炎炎症的抗氧化剂。漂白凝胶的过氧化氢(H 2 O 2)引起牙髓的炎症和坏死。在本研究中,我们评估了卡维地洛在漂白后大鼠牙髓中的抗炎作用。

大鼠右上臼齿接受35%H2O2(1×30分钟),左上臼齿作为对照。一半大鼠接受卡维地洛凝胶(1×10分钟),形成以下组:漂白,漂白,然后用卡维地洛(漂白+卡维地洛)和对照。在第2天和第30天(N = 7个半上颌/组)后,杀死大鼠进行组织学评估,并进行统计学检验(P <0.05)。

结果显示,2天后,漂白组在冠状牙髓的咬合三分之一处显示坏死,在漂白+卡维地洛组中,严重炎症(P> 0.05),均与对照组不同(P <0.05)。在中间三分之一,漂白组显示严重炎症,漂白+卡维地洛组显示中度炎症(P> 0.05),漂白组和对照组之间存在差异(P <0.05)。在宫颈三分之一,漂白组显示中度炎症,漂白+卡维地洛组显示轻度炎症(P> 0.05)。差异仅存在于漂白组和对照组之间(P <0.05)。 30天时,漂白牙齿无炎症和大量牙本质(P> 0.05)。

总之,该研究结果表明,卡维地洛凝胶具有最小化H2O2损伤的潜力,特别是在漂白后大鼠牙髓的深部区域。

原始出处:

Louzada LM, Briso ALF, et al., Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: A histopathological evaluation. J Investig Clin Dent. 2019 Jan 28:e12401. doi: 10.1111/jicd.12401. 

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    2019-04-09 jxrzshh
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    2019-02-10 1ddf0692m34(暂无匿称)

    学习了长知识

    0

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    2019-02-08 zhouqu_8
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    2019-02-08 lishizhe
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    2019-02-08 jambiya