Heart:经导管主动脉瓣植入术后合并症负担与临床结局的关联

2018-07-22 xiangting MedSci原创

在这项多中心国际性研究中,TAVI患者的合并症负担显著。研究发现CCI与完善的术前风险评分之间存在弱相关性。

这项研究旨在探讨经导管主动脉瓣植入术(TAVI)后Charlson合并症指数(CCI)与临床结局之间的关联。

TAVI患者的合并症负担较重;然而,关于合并症负担对临床结局影响的证据很少。

研究收集了2007年至2016年间来自英国、加拿大、西班牙、瑞士和意大利的1887名患者的数据。使用logistic回归和Cox比例风险模型,通过两阶段个体参与者数据(IPD)随机效应meta分析,计算了整个队列和不同国家CCI与30天死亡率的关联、瓣膜学术研究协会-2(VARC-2)复合早期安全性、长期生存率和住院时间(LoS)。

大多数患者(60%)的CCI≥3。总CCI与四种不同的术前风险评分之间存在弱相关性(ρ=0.16至0.29),约50%被四种风险预测模型归类为低风险的患者CCI≥3。总CCI每升高1个单位与30天死亡率升高(OR 1.09,95%CI 0.96至1.24)或VARC-2早期安全性不相关(OR 1.04,95%CI 0.96至1.14),但与长期死亡率风险升高相关(HR 1.10,95%CI 1.05-1.16)。两阶段IPD meta分析表明CCI与LoS无关(HR 0.97,95%CI 0.93-1.02)。

在这项多中心国际性研究中,TAVI患者的合并症负担显著。研究发现CCI与完善的术前风险评分之间存在弱相关性。CCI与TAVI后长达5年的长期死亡率呈中度相关。

原始出处:

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    2018-07-25 lvliquan
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time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562942, encodeId=2ddc15629423b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=)]
  5. 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time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562942, encodeId=2ddc15629423b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1797625, encodeId=45ad1e976255e, content=<a href='/topic/show?id=d2d523192bb' target=_blank style='color:#2F92EE;'>#主动脉瓣植入术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23192, encryptionId=d2d523192bb, topicName=主动脉瓣植入术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Mar 15 12:04:00 CST 2019, time=2019-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935935, encodeId=19a519359351a, content=<a href='/topic/show?id=6d06e826033' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78260, encryptionId=6d06e826033, topicName=经导管主动脉瓣植入)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520495, encodeId=064e1520495f3, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562942, encodeId=2ddc15629423b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=)]
    2018-07-24 zhaojie88
  7. 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  8. 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time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562942, encodeId=2ddc15629423b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Jul 24 08:04:00 CST 2018, time=2018-07-24, status=1, ipAttribution=)]
    2018-07-24 lsj631
  9. 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    2018-07-24 jiyangfei
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    2018-07-24 slcumt

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