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JCLA：不同免疫测定系统对全血他克莫司浓度的比较如何？

2019-01-17 MedSci MedSci原创

他克莫司浓度
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不同的自动免疫测定法测定他克莫司通常会出现不同测定值。本研究的目的是比较日本市场上主要的免疫测定系统检测血中他克莫司浓度的差异。 研究人员通过3种商业分析方法进行分析118例患者的全血样本，即化学发光酶免疫分析(CLIA)、亲和柱介导免疫分析(ACMIA)和酶多重免疫分析技术(EMIT)。采用液相色谱-串联质谱法(LC - MS/MS)进行分析。 免疫测定与LC‐MS/MS的相关系数对

不同的自动免疫测定法测定他克莫司通常会出现不同测定值。本研究的目的是比较日本市场上主要的免疫测定系统检测血中他克莫司浓度的差异。

研究人员通过3种商业分析方法进行分析118例患者的全血样本，即化学发光酶免疫分析(CLIA)、亲和柱介导免疫分析(ACMIA)和酶多重免疫分析技术(EMIT)。采用液相色谱-串联质谱法(LC - MS/MS)进行分析。

免疫测定与LC‐MS/MS的相关系数对ACMIA(0.83)和CLIA(0.81)极好，对EMIT(0.71)为良好。ACMIA的平均误差为负，CLIA和EMIT的平均误差为正。ACMIA和CLIA的平均绝对误差和均方根误差几乎相同，低于EMIT的平均绝对误差和均方根误差。

研究结果表明，ACMIA和CLIA在监测他克莫司血药浓度方面比EMIT的效果好得多。

原始出处：

Tetsuya Kaneko, Takashi Fujioka, Yosuke Suzuki, Comparison of whole‐blood tacrolimus concentrations measured by different immunoassay systems


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    2019-10-21 爆笑小医

    #测定#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1662280, encodeId=cd3d1662280eb, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Oct 21 18:34:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337766, encodeId=c68c133e76696, content=<a href='/topic/show?id=fbd825321ba' target=_blank style='color:#2F92EE;'>#他克莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25321, encryptionId=fbd825321ba, topicName=他克莫司)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Sat Jan 19 13:34:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544566, encodeId=e9e1154456617, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sat Jan 19 13:34:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358477, encodeId=aab83584e78d, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jan 17 23:12:25 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358476, encodeId=eb2f3584e684, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jan 17 22:53:34 CST 2019, time=2019-01-17, status=1, ipAttribution=)]
    2019-01-19 12498b08m90暂无昵称

    #他克莫司#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1662280, encodeId=cd3d1662280eb, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Oct 21 18:34:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337766, encodeId=c68c133e76696, content=<a href='/topic/show?id=fbd825321ba' target=_blank style='color:#2F92EE;'>#他克莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25321, encryptionId=fbd825321ba, topicName=他克莫司)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d0b2500136, createdName=12498b08m90暂无昵称, createdTime=Sat Jan 19 13:34:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544566, encodeId=e9e1154456617, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Sat Jan 19 13:34:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358477, encodeId=aab83584e78d, content=学习了，谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jan 17 23:12:25 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358476, encodeId=eb2f3584e684, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jan 17 22:53:34 CST 2019, time=2019-01-17, status=1, ipAttribution=)]
    2019-01-19 12498974m55暂无昵称

    #浓度#

    0

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    2019-01-17 惠映实验室

    学习了，谢谢分享。

    0

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    2019-01-17 orangesking

    看看

    0

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