Neurology:胎盘早剥与脑血管疾病

2019-08-17 xing.T MedSci原创

由此可见,胎盘早剥与脑血管病发病率和死亡率增加有关。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,该研究通过评估胎盘早剥女性卒中的发生率和死亡率来检验胎盘早剥是否与长期脑血管疾病有关。

研究人员设计了一项基于人群的前瞻性队列研究,该研究的对象为1978年至2010年期间在丹麦分娩的妇女。研究人员使用来自国家患者登记处、死亡原因登记处和丹麦出生登记处的数据来识别胎盘早剥、脑血管事件和死亡的妇女。结局包括卒中和非致命性缺血性和出血性卒中导致的死亡。研究人员针对卒中结局拟合Cox比例风险回归模型,调整了分娩年份、胎次、教育程度和吸烟情况。

正常妊娠组和胎盘早剥组的中位数(四分位间距)随访时间分别为15.9(7.8-23.8)和16.2(9.6-23.1)年,其中828289名女性随访了13231559人次每年。在伴有和不伴有卒中妇女中,脑血管死亡率分别为每10000人0.8和0.5人每年(风险比[HR]为1.6,95%置信区间[CI]为0.9-3.0)。胎盘早剥与非致命性缺血性卒中(HR为1.4,95%CI为1.1-1.7)和出血性卒中(HR为1.4,95%CI为1.1-1.9)的发生率增加有关。在有缺血性胎盘疾病和胎盘早剥次数超过2次的女性中,妊娠<34周就分娩的女性胎盘早剥和卒中之间的相关性增强。这些关联不太可能受到无法衡量的混淆因素的影响。

由此可见,胎盘早剥与脑血管病发病率和死亡率增加有关。

原始出处:

A population-based prospective cohort study.Neurology.2019.https://n.neurology.org/content/early/2019/08/16/WNL.0000000000008122

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    2019-10-03 yinhl1978
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