JACC:NT-proBNP指导下的心衰治疗花费更多且无益处

2018-11-21 MedSci MedSci原创

GUIDE-IT临床试验比较了N-末端B型利钠肽(NT-proBNP)指导下的心衰治疗和单纯的内科治疗在高风险心衰患者中的效果,但该研究因无明显作用而被提前终止。本研究的目的旨在评估GUIDE-IT临床试验中的治疗相关生活质量(QOL)和经济产出。本研究对GUIDE-IT临床试验患者中的基线、随机分组后3、6、12和24个月的QOL。在对446名随机分至NT-proBNP指导下心衰治疗组患者和44

GUIDE-IT临床试验比较了N-末端B型利钠肽(NT-proBNP)指导下的心衰治疗和单纯的内科治疗在高风险心衰患者中的效果,但该研究因无明显作用而被提前终止。本研究的目的旨在评估GUIDE-IT临床试验中的治疗相关生活质量(QOL)和经济产出。

本研究对GUIDE-IT临床试验患者中的基线、随机分组后3、6、12和24个月的QOL。在对446名随机分至NT-proBNP指导下心衰治疗组患者和448名被分至常规治疗组患者进行分析后,发现6个月后的QOL在NT-proBNP指导下心衰治疗组中明显更高,但在24个月时无明显差异。另外,平均总成本平均值在NT-proBNP指导下心衰治疗组中要高出5919美元。

研究结果显示,在高风险心衰伴射血分数降低患者中,N-末端B型利钠肽(NT-proBNP)指导下的心衰治疗花费更多,但效果无明显差异。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1854233, encodeId=dfe0185423387, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Mar 17 14:41:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289319, encodeId=7a60128931956, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290348, encodeId=c0a212903485e, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326044, encodeId=8b1b1326044d8, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602085, encodeId=f56d16020853f, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2019-03-17 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1854233, encodeId=dfe0185423387, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Mar 17 14:41:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289319, encodeId=7a60128931956, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290348, encodeId=c0a212903485e, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326044, encodeId=8b1b1326044d8, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602085, encodeId=f56d16020853f, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-23 huiwelcome
  3. [GetPortalCommentsPageByObjectIdResponse(id=1854233, encodeId=dfe0185423387, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Mar 17 14:41:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289319, encodeId=7a60128931956, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290348, encodeId=c0a212903485e, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326044, encodeId=8b1b1326044d8, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602085, encodeId=f56d16020853f, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-23 mjldent
  4. [GetPortalCommentsPageByObjectIdResponse(id=1854233, encodeId=dfe0185423387, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Mar 17 14:41:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289319, encodeId=7a60128931956, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290348, encodeId=c0a212903485e, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326044, encodeId=8b1b1326044d8, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602085, encodeId=f56d16020853f, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1854233, encodeId=dfe0185423387, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Mar 17 14:41:00 CST 2019, time=2019-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289319, encodeId=7a60128931956, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290348, encodeId=c0a212903485e, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1326044, encodeId=8b1b1326044d8, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602085, encodeId=f56d16020853f, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Nov 23 00:41:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-23 sunylz

相关资讯

Circulation:体重指数(BMI)与年轻人的心血管健康也密切相关

一直以来,身体质量指数(BMI)被认为与中年至老年心血管健康相关,但在年轻人中尚未进行过研究,也无详细的心血管表型。基因型重复分析(RbG)是一种能够在较小的研究中收集精确的表型测量数据,同时又能保持统计能力和因果推断的能力的方法。在本研究中,研究人员综合采用传统的多变量回归分析、孟德尔随机化(MR)和亚样本RbG方法来评估BMI对来年轻健康受试者的心血管健康的影响。根据MR和RbG分析,BMI越

JAHA:心脏外科术后心包切开综合征与死亡率的相关性研究

心包切开后综合征(PPS)是心脏外科手术后常见的并发症之一,然而尚缺乏大型关于手术类型对PPS影响及PPS对患者死亡率影响的流行病学研究。本研究搜索了芬兰国家数据库的28761名接受冠脉搭桥术、主动脉瓣置换术、二尖瓣置换术和升主动脉手术的患者,但仅纳入分析了PPS严重到住院或致死的患者。分析结果发现,在研究期间有493名患者发生PPS,与接受冠脉搭桥术相比,接受主动脉瓣置换术患者(HR:1.97;

JAHA:影响先心病外科手术后远期死亡风险的因素研究

既往对先天性心脏病手术的预后研究主要聚焦于早期的预后,而晚期的危险因素尚不清楚。本研究的目的旨在评估影响接受先天性心脏病手术儿童(<21岁)远期死亡的因素。本研究纳入了美国国家数据库中1982-2003年接受先天性心脏病外科手术的31132名患者,经过平均18年时间的随访,共有2527例死亡(8.1%),造成死亡的原因主要有术后的时间及先心病的严重程度,69.9%的死亡源于先心病或其他一种心血管疾

JAHA:心电图异常可预测致心律失常性心肌病的表型

本研究的目的旨在比较和评估致心律失常性心肌病的心电图和对比增强心脏磁共振的表现。本研究纳入分析了79例致心律失常性心肌病患者(男性占60%),并对其进行了心电图和心脏磁共振检查。分析结果显示,12导联心电图的广泛T波倒置与右室舒张末期容积增加(P<0.001)和右室射血分数降低(P<0.001)相关,侧导联的T波倒置预测更严重的右室舒张问题而非左室。右心前区导联(V1-V3)的终端激活

JAHA:2型糖尿病患者肥胖与不良预后的相关性研究

近期研究显示糖尿病患者可能存在肥胖悖论现象。本研究的目的旨在评估2型糖尿病患者的不良预后事件与肥胖的关系。本研究纳入了ACCORD 临床研究中的有10年2型糖尿病史的患者。主要终点事件是全因死亡率,次要终点事件是心源性死亡、非致死性心梗和卒中。分析结果显示,三级肥胖患者(BMI≥40)的全因死亡率最高,二级肥胖其次,超重患者的风险最小。患者的BMI与腰围存在相关性(r=0.802),BMI与主要和

JAHA:地高辛通过影响血小板激活水平影响房颤患者预后

地高辛的使用与房颤患者不良心血管事件的发生相关,本研究提出假设,地高辛可以通过血小板的激活影响心血管风险。本研究是房颤抗凝患者前瞻性研究的事后分析,将患者分成地高辛使用组(n=132)和非地高辛使用组(n=388),并对其测定了血小板活化标志物血栓烷B2(TxB2)的尿排泄量和血清地高辛浓度(SDC)。本研究也同时进行了体外实验,将对照和房颤患者的血小板体外培养,并用标准剂量的地高辛进行孵育(0.