J Periodontol: 牙周炎和唾液中胎盘生长因子是妊娠期糖尿病的早期预测因素

2018-09-25 MedSci MedSci原创

妊娠期糖尿病(GDM)影响约7%至10%的妊娠者。早期发现,GDM易感性是开发有效预防治疗的第一步。本研究的目的是确定胎盘蛋白在口腔液体(龈沟液[GCF]和唾液)中的应用,以及作为GDM早期妊娠预测因子的牙周病状态。

妊娠期糖尿病(GDM)影响约7%至10%的妊娠者。早期发现,GDM易感性是开发有效预防治疗的第一步。本研究的目的是确定胎盘蛋白在口腔液体(龈沟液[GCF]和唾液)中的应用,以及作为GDM早期妊娠预测因子的牙周病状态。

方法:研究纳入了年龄在18至40岁之间,孕11至14周,患不患GDM的孕妇。收集口腔液体样本并获得完整的妇科/产科和牙周病史。通过酶联免疫吸附测定胎盘生长因子(PlGF)和可溶性Fms样酪氨酸激酶1(sFlt-1)的浓度。多个逻辑回归模型评估了这种关联。通过ROC曲线,计算曲线下面积(AUC),评估生物标记物的诊断准确性。

结果:在怀孕11至14周时招募了212名孕妇,其中14名女性(即6.6%)患有GDM,并且在探诊时出血更多(BOP)[P = 0.0003];牙周探诊深度(PD)[P = 0.0028];临床附着水平(AL)[P = 0.0008]和牙周炎症表面积(PISA)[P = 0.0001]。同样,GDM女性的初始血糖和GCF-PlGF浓度显着升高[分别为P = 0.0012和P = 0.0019]。当对数据进行ROC曲线分析时,初始血糖和GCF-PlGF浓度的组合在ROC曲线下的面积为0.897。多因素Logistic回归分析显示发生GDM的女性血糖(OR 1.21,95%可信区间[CI] 1.06至1.38; P = 0.005)与GCF-PlGF浓度之间存在关联(OR 1.68,CI 1.05至2.68 P = 0.03) 。

结论:本研究结果证明,孕早期母亲血糖与GCF-PlGF浓度相结合可能成为未来女性GDM出现症状前的替代生物标志物。

原始出处:

Alejandra Chaparro, et al.Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus. Journal of  Periodontology. 2018 September. Doi:10.1002/JPER.17-0497

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    2019-09-05 feather89
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    2018-09-25 misszhang

    谢谢MedSci提供最新的资讯

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