Neurology:抗抑郁药的5-羟色胺再摄取抑制程度与缺血性卒中风险

2019-08-08 xing.T MedSci原创

由此可见,该基于人群的大型研究表明,强5-羟色胺再摄取抑制的抗抑郁药可能与缺血性卒中发生率的小幅下降有关。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,该研究旨在评估使用具有强烈抑制5-羟色胺再摄取的抗抑郁药是否与缺血性卒中和心肌梗塞(MI)的发生率降低有关。

研究人员使用英国临床实践研究数据链进行了一项队列研究,主要纳入了1995年至2014年间年龄为18岁的接受选择性5-羟色胺再摄取抑制剂(SSRIs)或第三代抗抑郁药的新用户。使用嵌套病例对照方法,研究人员在随访期间确定了首次缺血性卒中或MI的每个病例与年龄、性别、时间和随访持续时间的30个相匹配的对照者。研究人员使用条件logistic回归估计了与弱血清素再摄取抑制剂相比当前使用的强抑制剂每个结果的发生率比(RR)和95%置信区间(CI)。

该队列共纳入了938388名SSRIs患者(n=868755)或第三代抗抑郁药服用者(n=69633)。队列入组的平均年龄为46岁(女性为64%)。在随访期间,确定了15860例缺血性卒中和8626例MI,并分别与473712和258022例对照者相匹配。与目前服用弱5-羟色胺再摄取抑制剂相比,目前使用强抑制剂与缺血性卒中发生率降低相关(RR为0.88,95%CI为0.80-0.97),但在一些敏感性分析中效应量较小。强抑制剂和弱抑制剂的MI发生率相似(RR为1.00,95%CI为0.87-1.15)。 

由此可见,该基于人群的大型研究表明,强5-羟色胺再摄取抑制的抗抑郁药可能与缺血性卒中发生率的小幅下降有关。
 
原始出处:

Antonios Douros,et al.Degree of serotonin reuptake inhibition of antidepressants and ischemic risk A cohort study.Neurology.2019.https://n.neurology.org/content/early/2019/08/06/WNL.0000000000008060

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    2020-06-30 yinhl1978
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createdName=yinhl1978, createdTime=Tue Jun 30 01:36:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806340, encodeId=214418063400b, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Sep 10 01:36:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778866, encodeId=1fa21e788663a, content=<a href='/topic/show?id=c63c140461' target=_blank style='color:#2F92EE;'>#5-羟色胺再摄取#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1404, 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content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 12:36:00 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1893199, encodeId=055a1893199d5, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Mar 15 06:36:00 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000839, encodeId=1662200083923, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, 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href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sat Aug 10 00:36:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026426, encodeId=0e11102642691, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Aug 08 12:36:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045881, encodeId=7d45104588192, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 12:36:00 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2020-05-30 wetgdt
  6. 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  7. 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  8. 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  9. 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content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 12:36:00 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2019-08-08 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 08 12:36:00 CST 2019, time=2019-08-08, status=1, ipAttribution=)]
    2019-08-08 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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