Eur Heart J:西地那非不能改善心脏瓣膜置换术后持续性肺动脉高压患者预后

2018-04-16 MedSci MedSci原创

本研究的目的旨在探究西地那非是否能改善心脏瓣膜疾病(VHD)矫正后持续性肺动脉高压患者的预后。本次多中心随机双盲对照临床研究纳入了200名1年前接受过心脏瓣膜置换术且平均肺动脉压力≥30mmHg的成年患者,其中104名患者接受了西地那非治疗,96名患者接受了安慰剂治疗,时间长达6个月,主要终点事件是死亡、心衰入院、功能分级改变和患者自我评估的临床综合评分。分析结果显示,西地那非组仅27名患者的临床

本研究的目的旨在探究西地那非是否能改善心脏瓣膜疾病(VHD)矫正后持续性肺动脉高压患者的预后。

本次多中心随机双盲对照临床研究纳入了200名1年前接受过心脏瓣膜置换术且平均肺动脉压力≥30mmHg的成年患者,其中104名患者接受了西地那非治疗,96名患者接受了安慰剂治疗,时间长达6个月,主要终点事件是死亡、心衰入院、功能分级改变和患者自我评估的临床综合评分。分析结果显示,西地那非组仅27名患者的临床综合评分有所改善,而对照组是44名,另外西地那非组有33名患者评分反而下降,对照组是14名(OR:0.39; 95% CI: 0.22-0.67; P?<?0.001)。此外,6分钟步行实验、钠尿肽水平和收缩期肺动脉压力在两组之间无明显差异。

研究结果显示,对于心脏瓣膜疾病矫正术后持续性肺动脉高压患者,西地那非反而会恶化患者的临床预后。

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    2018-12-19 柚苏子。

    学习了

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307414, encodeId=b22d30e414b8, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Fri Apr 20 04:54:00 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1691976, encodeId=6a9316919e63a, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Fri Jun 22 23:39:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808606, encodeId=6781180860648, content=<a href='/topic/show?id=eade820e7c0' target=_blank style='color:#2F92EE;'>#肺动脉高压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82077, encryptionId=eade820e7c0, topicName=肺动脉高压患者)], attachment=null, authenticateStatus=null, createdAvatar=, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307414, encodeId=b22d30e414b8, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Fri Apr 20 04:54:00 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
    2018-06-27 yxch48
  10. 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    2018-04-20 哈哈869

    学了

    0

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