Sci Rep:出生顺序会影响身体质量指数(BMI)和胰岛素敏感性吗?

2014-03-24 Nature中文网 Nature中文网

对50个超重的中年男子所做的一项研究表明,第一个出生的人比第二个出生的人更可能有较大的身体质量指数(BMI)和对胰岛素的较低敏感性。发表在本期Scientific Reports上的这项研究增进了我们对出生顺序的潜在长期健康影响的认识,尽管还需要进行将“同胞对”包括在内的更大规模的研究来全面评估这一联系。 一些证据表明,出生顺序从婴儿期到成年早期可能会影响代谢和身体组成,但中年时期的潜在影响此前

对50个超重的中年男子所做的一项研究表明,第一个出生的人比第二个出生的人更可能有较大的身体质量指数(BMI)和对胰岛素的较低敏感性。发表在本期Scientific Reports上的这项研究增进了我们对出生顺序的潜在长期健康影响的认识,尽管还需要进行将“同胞对”包括在内的更大规模的研究来全面评估这一联系。

一些证据表明,出生顺序从婴儿期到成年早期可能会影响代谢和身体组成,但中年时期的潜在影响此前仍未得到研究。Wayne Cutfield及同事研究了50个年龄在40岁和50岁之间的虽然超重但在其他方面却健康的男子,这些人是为进行两个互不相关的临床试验而招来的。他们报告说,第一个出生的人倾向于比第二个出生的人重6.9公斤,BMI也较大。第一个出生的男子比二个出生的男子胰岛素敏感性也低33%,尽管该指标已经针对身体脂肪含量做了调整。

该研究为出生顺序对代谢健康的可能影响提供了一个宽泛评估。但作者指出,参加研究者的范围相当狭窄(生活在一个大城市中心地区的超重男子),而且由于没有对“同胞对”进行研究,所以这项研究有可能低估了出生顺序对胰岛素敏感性和其他代谢指标的影响程度。

原始出处

Albert BB1, de Bock M1, Derraik JG1, Brennan CM1, Biggs JB1, Hofman PL2, Cutfield WS2.Among overweight middle-aged men, first-borns have lower insulin sensitivity than second-borns.Sci Rep. 2014 Feb 6

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    2014-12-02 baoya
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