JAHA:冠状动脉钙化进展与心力衰竭有何关系?

2017-04-22 xing.T MedSci原创

由此可见,在后续的随访检查中,CAC进展与HF发生和适度增加的LV舒张末期容积和LV收缩末期容积相关,并且独立于明显的冠心病。

虽然以前的研究已经显示冠状动脉钙化(CAC)和未来的心脏衰竭(HF)之间存在相关性,但CAC进展在HF预测中的价值尚不清楚。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,在这项研究中,研究人员通过动脉粥样硬化的多民族研究调查了CAC进展与亚临床左心室(LV)功能障碍和HF发生之间的相关性。

动脉粥样硬化多民族研究是一项以人群为基础的研究,由6814名45岁至84岁的男性和女性组成,在招募之时这些参与者无明显的心血管疾病,他们来自于4个民族。研究人员纳入了5644名动脉粥样硬化多民族研究的参与者,这些参与者在基线和随访中进行了心脏计算机断层扫描,并且在第二次心脏计算机断层扫描前没有HF和冠心病。

这些参与者平均年龄为61.7±10.2岁,男性占47.2%。Cox比例风险模型和多元线性回归模型被分别用来明确CAC进展与HF发生和亚临床LV功能障碍之间的相关性。在中位随访了9.6年(间距范围:8.8-10.6),182名参与者发展为心衰。CAC进展每年10个单位与HF的风险增加3%相关,并且独立于明显的冠状动脉心脏疾病(P=0.008)。在2818名有心脏磁共振图像的患者中,CAC进展与LV舒张末期容积增加(β=0.16;P=0.03)和左室收缩末期容积(β=0.12;P=0.006)相关,在排除了任何冠心病患者外。

由此可见,在后续的随访检查中,CAC进展与HF发生和适度增加的LV舒张末期容积和LV收缩末期容积相关,并且独立于明显的冠心病。

原始出处:


Hooman Bakhshi,et al. Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis.JAHA.2017. https://doi.org/10.1161/JAHA.116.005253

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-24 zhaohui6731
  5. 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level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-24 1e0ece0dm09(暂无匿称)

    谢谢指点迷津

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-24 lemon985

    有关系

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 1e15b6fem30(暂无匿称)

    很好的学习资料,感谢了。

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Mon Apr 24 00:10:21 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189966, encodeId=8e201899660b, content=很好的学习资料,感谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Sun Apr 23 18:22:55 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189957, encodeId=a72218995e44, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 wxl882001

    学习一下

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Mon Apr 24 00:10:21 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189966, encodeId=8e201899660b, content=很好的学习资料,感谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Sun Apr 23 18:22:55 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189957, encodeId=a72218995e44, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 Chongyang Zhang

    签到学习了很多

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca432042642, createdName=lemon985, createdTime=Mon Apr 24 00:10:21 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189966, encodeId=8e201899660b, content=很好的学习资料,感谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Sun Apr 23 18:22:55 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189957, encodeId=a72218995e44, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Apr 23 17:28:20 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189928, encodeId=192b189928d4, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Sun Apr 23 14:18:49 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189872, encodeId=9c991898e23a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Apr 23 12:00:52 CST 2017, time=2017-04-23, status=1, ipAttribution=)]
    2017-04-23 飛歌

    学习了很有用

    0

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冠状动脉钙化(CAC)与房颤风险增加相关,那么随着时间的推移,CAC进展速度是否与房颤增加有关呢? 本研究收纳了5612名参与者(平均年龄:62±10岁;52%的女性,39%的白人,27%的黑人,20%的西班牙裔,12%的华裔美国人)。研究人员通过利用心脏CT评估受试者的CAC,使用影像校正Agatston评分计算每年的CAC变化(≤0,1–100,101–300与>300 U/年)。通过

JAHA:主动脉钙化与冠状动脉粥样硬化的发生相关!

由此可见,TAC和CAC共享着类似的发生钙化的主要决定因素。TAC参与者,特别是升TAC的参与者,发展为CAC的风险升高。

JAMA:心脏瘢痕的患病率及发病原因大揭秘

心肌瘢痕导致民众心脏功能减退,且预后不良。但迄今为止对于民众患心肌瘢痕的患病率及与发生心肌梗死的关联尚不明确。且对于多民族的美国民众而言,心肌瘢痕尚无准确定义

Eur Heart J:CAC、CIMT与ABI在预测心血管事件上,哪个更好?

由此可见,CAC提供了最好的风险区分相比于CIMT和ABI,特别是在中度风险组,而CIMT可能是低风险组最好的替代指标。

JACC子刊:冠状动脉钙化与CVD预后独立相关

目的:作者旨在确定基线冠状动脉钙化(CAC),随访CAC 及,CAC进展对心血管疾病(CVD)的影响。背景:重复CAC扫描已被提议作为跟踪总动脉粥样硬化负荷的方法。然而, CAC进展是否是未来心血管事件的预测因子尚不清楚。方法:这是一项前瞻性观察性研究,共5933名无心血管疾病患者,进行了2项检查,包括CAC评分,和随后的心血管事件的评估。用平方根法计算CAC的进展。主要终点为总体心血管事件(CV