双重PPAR激动剂治疗非酒精性脂肪性肝炎:III期临床宣布失败

2020-07-24 MedSci原创 MedSci原创

Genfit宣布终止elafibranor治疗患有纤维化非酒精性脂肪性肝炎(NASH)患者的III期试验。

Genfit宣布终止elafibranor治疗患有纤维化非酒精性脂肪性肝炎(NASH)患者的III期试验。

此举是在对III期RESOLVE-IT试验数据的中期分析之后得出的,数据分析表明,该双重PPAR激动剂未能达到主要疗效终点:缓解NASH且纤维化未恶化。

See the source image

图片来源:https://www.slideshare.net/SantoshNarayankar/nafld-management-challengesinvolved

在对数据进行详细审查之后,该公司决定放弃,认为现有数据不足以支持elafibranor在美国和欧洲的营销申请。

Genfit指出这项决定是公司战略的重要一步,节约成本并集中精力于原发性胆管性胆管炎(PBC)的弹性纤维化治疗以及NIS4的商业化发展用于NASH诊断

原始出处:

http://www.pharmatimes.com/news/end_of_the_line_for_genfits_experimental_nash_drug_1345327

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time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594774, encodeId=59241594e74d0, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Jul 26 05:43:14 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627827, encodeId=20c8162e827de, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, 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  5. 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time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594774, encodeId=59241594e74d0, content=<a href='/topic/show?id=b317956200' target=_blank style='color:#2F92EE;'>#III期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9562, encryptionId=b317956200, topicName=III期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Jul 26 05:43:14 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627827, encodeId=20c8162e827de, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Sun Jul 26 05:43:14 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
    2021-03-10 juliusluan78
  6. 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  7. 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