JAHA:血小板凝聚状态能预测冠心病患者的临床风险?

2017-08-07 MedSci MedSci原创

既往研究表明,在冠心病患者中,在接受抗血小板治疗期间出现不断升高的血小板聚集可能会增加心血管不良事件的发生风险,而大多数冠心病患者接受的是单一的阿司匹林治疗。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估接受阿司匹林治疗的稳定冠心病患者的高血小板凝聚水平是否会增加心血管不良事件的发生风险的临床研究。本研究纳入了900例有心梗病史或2型糖尿病病史的稳定冠心病患者,所有患者均接受单一的每天75

既往研究表明,在冠心病患者中,在接受抗血小板治疗期间出现不断升高的血小板聚集可能会增加心血管不良事件的发生风险,而大多数冠心病患者接受的是单一的阿司匹林治疗。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估接受阿司匹林治疗的稳定冠心病患者的高血小板凝聚水平是否会增加心血管不良事件的发生风险的临床研究。

本研究纳入了900例有心梗病史或2型糖尿病病史的稳定冠心病患者,所有患者均接受单一的每天75mg的阿司匹林抗血小板治疗,血小板凝聚状态通过专门的试剂盒在患者服用阿司匹林1小时后进行检测,主要终点事件是非致命的心梗、缺血性休克和心源性死亡。经过3年的随访,有78例主要终点事件被记录下来。研究结果显示,高血小板凝聚状态的患者的主要终点事件发生率与其他患者相比并没有显着的升高,在复合次要终点事件(非致命性心梗、缺血性卒中、支架栓塞和全因死亡)或单一终点事件中也没有显着的差异。血栓素B2的水平不能预测心血管不良事件,肾功能不全是唯一能预测主要终点事件的临床危险因子。

本研究是最大的评估接受阿司匹林治疗的稳定冠心病患者的高血小板凝聚水平是否会增加心血管不良事件的发生风险的临床研究。研究结果显示,高水平的血小板凝聚状态不会增加心血管不良事件的发生风险。

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    2017-09-16 海之蓝

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    2017-09-12 海之蓝

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    2017-09-02 海之蓝

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    0

  4. 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encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Aug 09 10:54:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447704, encodeId=98e6144e7043a, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Wed Aug 09 10:54:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231638, encodeId=a5b62316387b, content=挺好的,学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-14 大爰

    学习了谢谢分享!!

    0

  5. 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encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Aug 09 10:54:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447704, encodeId=98e6144e7043a, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Wed Aug 09 10:54:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231638, encodeId=a5b62316387b, content=挺好的,学习了谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-10 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-09 zhaohui6731
  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-09 lou.minghong

    挺好的,学习了谢谢分享!

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-08 1821f7b326m

    还好还好,我血小板常年异常

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed Aug 09 01:16:30 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231418, encodeId=42392314188e, content=还好还好,我血小板常年异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7412106448, createdName=1821f7b326m, createdTime=Tue Aug 08 09:50:42 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231347, encodeId=f14523134e3f, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Tue Aug 08 06:54:08 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2017-08-08 130****4638

    学习了受益匪浅

    0

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目前,对于先天性心脏病的治疗,经导管介入治疗已经代替了许多外科治疗,比如房间隔缺损修补。但是,一些复杂的先心病仍然需要外科的开胸手术治疗,有些甚至需要多期的开胸外科治疗,这就不可避免地伴随着较高的死亡率。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估在一个病人中仅经导管操作行大血管吻合术(上腔静脉和肺动脉吻合术)的可行性的临床研究。 研究者在近十年一直在探索非外科方法的大血管吻合方法