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ISUOG 2014：早期妊娠胎儿心轴和先天性心脏缺陷的多中心病例对照研究

2014-10-09 曹艳华 译 医学论坛网

早期妊娠胎儿先天性心脏缺陷对照研究
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在第24届世界妇产科学超声大会上，美国东部维吉尼亚州医学院妇产科学者E. Sinkovskaya报告了将测量胎儿心轴(CAx)作为早期妊娠先天性心脏病(CHD)筛查方法的可行性。         在197例确诊为CHD的胎儿中，评估妊娠11 + 0至14 + 6周的胎儿的CAx。排除右转和右移位胎儿。CAx是指在

在第24届世界妇产科学超声大会上，美国东部维吉尼亚州医学院妇产科学者E. Sinkovskaya报告了将测量胎儿心轴(CAx)作为早期妊娠先天性心脏病(CHD)筛查方法的可行性。

在197例确诊为CHD的胎儿中，评估妊娠11 + 0至14 + 6周的胎儿的CAx。排除右转和右移位胎儿。CAx是指在四心腔观面心脏长轴线与冠状位平分胸腔线间的角度。对照组需匹配每个CHD病例的2个因素，即相似顶臀长(CRL)(±1 mm)和研究日期(±2个月)。

结果发现，对照组CAx波动于27.4到63.9°(平均数为43.6±8.5)。这个参数在早期和中期妊娠期间无显著变化。CHD 组中51/197胎儿CAx在正常范围内，并波动于33到59°。146/197胎儿CAx异常，包括110例左偏差(CAx>95 %值),19例右偏差(CAx < 5%值)和17例未识别CAx。胎儿颈项后透明带厚度 (NT)和CAx测量作为有正常和异常核型胎儿的CHD筛查方法结果见表格1。

作者由此得出结论，三分之二的早期妊娠CHD胎儿为异常CAx。CAx评估和胎儿颈项后透明带厚度超声联合检查有助于鉴别易患胎儿CHD的高危人群。

信源地址：http://onlinelibrary.wiley.com/doi/10.1002/uog.2014.44.issue-S1/issuetoc


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    2014-12-22 fengyi812

    #病例对照研究#

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    2014-12-06 xugc

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    2015-01-12 luoxiaog

    #多中心#

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    2014-10-11 huirong

    #先天性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1984121, encodeId=3a91198412186, content=<a href='/topic/show?id=77dee0776b6' target=_blank style='color:#2F92EE;'>#病例对照研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70776, encryptionId=77dee0776b6, topicName=病例对照研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Mon Dec 22 15:58:00 CST 2014, time=2014-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756150, encodeId=953c1e561505a, content=<a href='/topic/show?id=cc81e0775ab' target=_blank style='color:#2F92EE;'>#病例对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70775, encryptionId=cc81e0775ab, topicName=病例对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=064637073830, createdName=xugc, createdTime=Sat Dec 06 11:58:00 CST 2014, time=2014-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775277, encodeId=f7ab1e7527729, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Mon Sep 21 18:58:00 CST 2015, time=2015-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903896, encodeId=aa2a1903896fa, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Mon Jan 12 03:58:00 CST 2015, time=2015-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369194, encodeId=bc981369194f0, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sat Oct 11 04:58:00 CST 2014, time=2014-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464303, encodeId=507d1464303df, content=<a href='/topic/show?id=5069593e079' target=_blank style='color:#2F92EE;'>#早期妊娠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59370, encryptionId=5069593e079, topicName=早期妊娠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24476662947, createdName=lhlxtx, createdTime=Sat Oct 11 04:58:00 CST 2014, time=2014-10-11, status=1, ipAttribution=)]
    2014-10-11 lhlxtx

    #早期妊娠#

    0