BMJ:减重手术增加骨折风险

2016-08-22 MedSci BMJ

肥胖是当今世界最为常见的健康问题之一。减重手术对于减轻体重和减少肥胖的并发症具有很好的效果。在很多发达国家中,减重手术的应用越来越多。但也有人担心减重手术可能会影响骨骼健康,比如骨密度减低等,目前在这方面的研究文章并不多。另一方面,衡量减重手术前后骨折风险到底如何,对于减重手术患者术前术后的管理十分重要。近日,《英国医学杂志》(The BMJ)发表了一篇关于这一课题的研究文章。该研究为回顾性巢式病

肥胖是当今世界最为常见的健康问题之一。减重手术对于减轻体重和减少肥胖的并发症具有很好的效果。在很多发达国家中,减重手术的应用越来越多。但也有人担心减重手术可能会影响骨骼健康,比如骨密度减低等,目前在这方面的研究文章并不多。另一方面,衡量减重手术前后骨折风险到底如何,对于减重手术患者术前术后的管理十分重要。近日,《英国医学杂志》(The BMJ)发表了一篇关于这一课题的研究文章。

该研究为回顾性巢式病例对照研究,研究目的为探寻减重手术是否增加骨折风险。研究对象为加拿大魁北克省在2001-2014年间进行减重手术的患者。共有12,676名患者进行减重手术,这些患者组成研究组;通过年龄和性别匹配选择了38,028名肥胖患者和126,760名非肥胖者作为对照组。主要终点事件为骨折发生的概率和部位。

研究结果:在手术之前,进行减重手术的患者(共1326例骨折,占10.5%)比肥胖(3065, 8.1%))或非肥胖(8329, 6.6%)对照组人群更容易出现骨折。进行手术平均4.4年后,进行减重手术的患者(514, 4.1%)与控制组的肥胖(1013, 2.7%)及非肥胖者(3008, 2.4%)相比也更易骨折。减重手术患者组的术后调整骨折风险高于控制组的肥胖(RR 1.38, 95%CI 1.23-1.55)和非肥胖(1.44, 1.29-1.59)人群。在研究组内部,手术后远端下肢骨折风险降低(RR 0.66, 0.56-0.78),但上肢骨折(1.64, 1.40-1.93))、脊柱骨折(1.78, 1.08-2.93)、髋关节骨折(2.52, 1.78-3.59)风险都增加了。

研究结论:进行减重手术的患者与肥胖者或非肥胖者相比更易出现骨折,且术后出现骨折的风险仍很高。骨折风险评估和管理应该作为减重手术治疗中的一部分。

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    2016-08-27 gaoxiaoe
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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-09-07 李东泽

    很好,不错,以后会多学习

    0

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    2016-08-30 ylzr123

    好文,值得学习,赞!

    0

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    2016-08-27 ylzr123

    赞!文章有深度,值得收藏拜读。

    0

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    2016-08-22 KO229256262

    根源是肥胖

    0