Nat Genet:什么基因决定你的长相?

2018-02-22 海北 MedSci原创

人脸是由不同特征(眼睛,鼻子,下巴和嘴巴)组成的,其大小,形状和构成显然是可遗传的。然而,至今为止,我们仍然缺乏关于哪些遗传变异能够导致人类面部变化的认识。

人脸是由不同特征(眼睛,鼻子,下巴和嘴巴)组成的,其大小,形状和构成显然是可遗传的。然而,至今为止,我们仍然缺乏关于哪些遗传变异能够导致人类面部变化的认识。

近日,来自比利时鲁汶大学的研究人员报告了一种数据驱动的方法,用于在多个层面对面部形状进行表型分析,可以在保留统计效能的同时对面部变化进行开放式描述。在一个2329位欧洲血统的样本研究中,研究人员确定了38个基因位点,其中15个位于欧洲独立样本(n = 1,719)中。四个位点是全新的。对于其他位点,在文献中发现了额外的支持(n = 9)或多效性(n = 2),但是这里报告的结果对其有了进一步的改进。

所有15个重复的基因座突出显示了面部形状的全局到局部遗传效应的独特模式,并且显示人类颅神经嵴细胞中活性染色质元素的富集,可能捕获到了面部差异的早期发育起源。

这些结果对面部遗传学和其他复杂形态特征的研究具有参考意义。


原始出处:

Peter Claes et al. Genome-wide mapping of global-to-local genetic effects on human facial shapeNature Genetics, 2018; DOI: 10.1038/s41588-018-0057-4


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    2019-02-07 liye789132251
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    2018-07-19 cy0324
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    2018-08-20 canlab
  5. [GetPortalCommentsPageByObjectIdResponse(id=1882864, encodeId=69f518828647e, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Feb 07 17:03:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1686180, encodeId=f43e1686180fd, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Sun Apr 22 11:03:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048984, encodeId=4f902048984fa, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Jul 19 21:03:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733976, encodeId=42fc1e339768e, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Aug 20 11:03:00 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292868, encodeId=5e75292868ff, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Mar 04 09:05:48 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291751, encodeId=f13d291e51ae, content=学了......, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Feb 28 18:13:13 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289936, encodeId=fd2328993650, content=努力学习.好好看下, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Feb 22 13:42:24 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289906, encodeId=7f0a28990638, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Feb 22 10:14:12 CST 2018, time=2018-02-22, status=1, ipAttribution=)]
    2018-03-04 龙胆草

    学习谢谢分享

    0

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    2018-02-28 135****7952平儿

    学了......

    0

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    2018-02-22 忠诚向上

    努力学习.好好看下

    0

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    2018-02-22 龙胆草

    学习谢谢分享

    0

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