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Blood：C5补体抑制剂Crovalimab治疗阵发性夜间血红蛋白尿

2020-02-01 QQY MedSci原创

C5补体Crovalimab阵发性夜间血红蛋白尿
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抑制补体C5是有明显临床症状的阵发性夜间血红蛋白尿(PNH)患者的标准护理(SoC)。持续完全抑制末端补体途径和高血清浓度的C5对药物开发构成挑战，导致只能采用静脉注射(IV)治疗。Crovalimab，一种序贯单克隆抗体回收技术(SMART)抗体，用于C5抑制疾病的皮下给药。近期，研究人员开展了一项三部分的开放性适应性I/II期试验，以评估Crovalimab在健康志愿者（部分一）、未进行过补体

抑制补体C5是有明显临床症状的阵发性夜间血红蛋白尿(PNH)患者的标准护理(SoC)。持续完全抑制末端补体途径和高血清浓度的C5对药物开发构成挑战，导致只能采用静脉注射(IV)治疗。

Crovalimab，一种序贯单克隆抗体回收技术(SMART)抗体，用于C5抑制疾病的皮下给药。

近期，研究人员开展了一项三部分的开放性适应性I/II期试验，以评估Crovalimab在健康志愿者（部分一）、未进行过补体阻滞的PNH患者（部分二）和C5抑制剂治疗的PNH患者（部分三）中的安全性、药代动力学、药效学和疗效。29位患者被纳入部分二（10位）和部分三（19位）研究。

Crovalimab浓度超过了预定的100μg/mL，导致部分二和部分三研究的患者的末端补体途径被持续完全抑制。溶血活性和游离C5水平被抑制在临床相关阈值以下。安全性与已知的C5抑制谱一致。

一如预期，所有19例改用Crovalimab的患者均观察到药物靶点-药物复合物(DTDC)的形成，2/19位患者出现短暂的轻中度血管性皮肤反应。这两个事件均在持续应用Crovalimab治疗后得到解决。

每4周皮下注射一次crovalimab（680mg），可为PNH患者提供持续完全的末端补体途径抑制，为进一步的临床发展提供了保障。

原始出处：

Alexander Roth， et al.The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria.Blood. January 24， 2020. 

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    2020-09-26 jklm09

    #抑制剂#

    0

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    2020-11-15 ms6000000249002173

    请问C5补体有买吗？

    0

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    2020-08-21 jiafufeng@yaho

    #CRO#

    0

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    2020-02-19 snf701207

    #mAb#

    0

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    2020-03-02 zhwj

    #阵发性夜间血红蛋白尿#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1852258, encodeId=25ed185225882, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Sep 26 08:28:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899285, encodeId=b82989928574, content=请问C5补体有买吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ac15434977, createdName=ms6000000249002173, createdTime=Sun Nov 15 10:53:36 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857857, encodeId=36bb185e8578a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Fri Aug 21 05:28:00 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912299, encodeId=0147191229934, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Feb 19 20:28:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723816, encodeId=fbb71e238163f, content=<a href='/topic/show?id=2e779e62647' target=_blank style='color:#2F92EE;'>#阵发性夜间血红蛋白尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97626, encryptionId=2e779e62647, topicName=阵发性夜间血红蛋白尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0be633545399, createdName=zhwj, createdTime=Mon Mar 02 15:28:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650579, encodeId=308d16505e93a, content=<a href='/topic/show?id=64ae90120b4' target=_blank style='color:#2F92EE;'>#补体抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90120, encryptionId=64ae90120b4, topicName=补体抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6df24038723, createdName=yahu, createdTime=Fri Feb 28 01:28:00 CST 2020, time=2020-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454920, encodeId=de3d145492080, content=<a href='/topic/show?id=6de952e48d' target=_blank style='color:#2F92EE;'>#Crovalimab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5274, encryptionId=6de952e48d, topicName=Crovalimab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e25610531, createdName=jml2011, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625897, encodeId=a17b162589ea3, content=<a href='/topic/show?id=776e392006' target=_blank style='color:#2F92EE;'>#C5补体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3920, encryptionId=776e392006, topicName=C5补体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d50820925144, createdName=xlwang2698, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=)]
    2020-02-28 yahu

    #补体抑制剂#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1852258, encodeId=25ed185225882, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Sep 26 08:28:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899285, encodeId=b82989928574, content=请问C5补体有买吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ac15434977, createdName=ms6000000249002173, createdTime=Sun Nov 15 10:53:36 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857857, encodeId=36bb185e8578a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Fri Aug 21 05:28:00 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912299, encodeId=0147191229934, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Feb 19 20:28:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723816, encodeId=fbb71e238163f, content=<a href='/topic/show?id=2e779e62647' target=_blank style='color:#2F92EE;'>#阵发性夜间血红蛋白尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97626, encryptionId=2e779e62647, topicName=阵发性夜间血红蛋白尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0be633545399, createdName=zhwj, createdTime=Mon Mar 02 15:28:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650579, encodeId=308d16505e93a, content=<a href='/topic/show?id=64ae90120b4' target=_blank style='color:#2F92EE;'>#补体抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90120, encryptionId=64ae90120b4, topicName=补体抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6df24038723, createdName=yahu, createdTime=Fri Feb 28 01:28:00 CST 2020, time=2020-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454920, encodeId=de3d145492080, content=<a href='/topic/show?id=6de952e48d' target=_blank style='color:#2F92EE;'>#Crovalimab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5274, encryptionId=6de952e48d, topicName=Crovalimab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e25610531, createdName=jml2011, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625897, encodeId=a17b162589ea3, content=<a href='/topic/show?id=776e392006' target=_blank style='color:#2F92EE;'>#C5补体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3920, encryptionId=776e392006, topicName=C5补体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d50820925144, createdName=xlwang2698, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=)]
    2020-02-03 jml2011

    #Crovalimab#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1852258, encodeId=25ed185225882, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Sep 26 08:28:00 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899285, encodeId=b82989928574, content=请问C5补体有买吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ac15434977, createdName=ms6000000249002173, createdTime=Sun Nov 15 10:53:36 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857857, encodeId=36bb185e8578a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Fri Aug 21 05:28:00 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912299, encodeId=0147191229934, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Wed Feb 19 20:28:00 CST 2020, time=2020-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723816, encodeId=fbb71e238163f, content=<a href='/topic/show?id=2e779e62647' target=_blank style='color:#2F92EE;'>#阵发性夜间血红蛋白尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97626, encryptionId=2e779e62647, topicName=阵发性夜间血红蛋白尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0be633545399, createdName=zhwj, createdTime=Mon Mar 02 15:28:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650579, encodeId=308d16505e93a, content=<a href='/topic/show?id=64ae90120b4' target=_blank style='color:#2F92EE;'>#补体抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90120, encryptionId=64ae90120b4, topicName=补体抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6df24038723, createdName=yahu, createdTime=Fri Feb 28 01:28:00 CST 2020, time=2020-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454920, encodeId=de3d145492080, content=<a href='/topic/show?id=6de952e48d' target=_blank style='color:#2F92EE;'>#Crovalimab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5274, encryptionId=6de952e48d, topicName=Crovalimab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e25610531, createdName=jml2011, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625897, encodeId=a17b162589ea3, content=<a href='/topic/show?id=776e392006' target=_blank style='color:#2F92EE;'>#C5补体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3920, encryptionId=776e392006, topicName=C5补体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d50820925144, createdName=xlwang2698, createdTime=Mon Feb 03 02:28:00 CST 2020, time=2020-02-03, status=1, ipAttribution=)]
    2020-02-03 xlwang2698

    #C5补体#

    0

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