J Clin Periodontol:结扎致小鼠种植体周围炎及牙周炎

2018-01-29 MedSci MedSci原创

种植体周围炎(PI),种植体周围的炎症,与牙周炎(PD)表现相似。然而,PI更难以控制和治疗,详细的病理生理学机制尚不清楚。我们旨在比较使用鼠模型的PI和PD进展。

种植体周围炎(PI),种植体周围的炎症,与牙周炎(PD)表现相似。然而,PI更难以控制和治疗,详细的病理生理学机制尚不清楚。我们旨在比较使用鼠模型的PI和PD进展。

四周龄雄性C57BL / 6J小鼠拔除左侧上颌磨牙。植入物被置入在愈合的拔牙窝和骨整合。结扎种植体和第二磨牙。对照组不结扎。于1周,1个月和3个月将小鼠处死(n≥5/组/时间点)。进行骨吸收分析。 组织学分析:(H&E),抗酒石酸酸性磷酸酶(TRAP),基质金属蛋白酶-8(MMP-8),活化B细胞核因子κ-轻链增强子(NF-κB),甲苯胺蓝色和钙黄绿素。与1个月和3个月的PD相比,PI显示有更多的骨吸收。在3个月时,PI中20%的种植体脱落; PD中没有天然牙脱落。 H&E显示PI种植体周围的牙槽骨比PD骨密度低。与PD相比,PI破骨细胞,MMP-8和NF-κB增多。

结论:与PD相比,PI组织和骨质破坏更重。未来需要进一步这两种疾病之间的病理生理差异。

原始出处:

Sarah Hiyari, et al. Ligature-induced peri-implantitis and periodontitis in mice. Journal of Clinical Periodontology. 2018 January. doi:10.1111/jcpe.12817

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    2018-09-11 huangdf
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    2018-07-04 feather89
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    2018-01-29 神功盖世

    0

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