Arthritis Rheumatol：吸烟、HLA基因和类风湿性关节炎的血清学

2019-02-20 xiangting MedSci原创

这项研究结果表明在4个血清学定义的RA亚组中，吸烟和HLA-DRB1有不同影响。

吸烟与由存在抗瓜氨酸蛋白抗体（ACPA）和类风湿因子（RF）所定义的RA亚组风险升高相关，并且吸烟与HLA-DRB1 SE间的相互作用仅限于血清学阳性RA的风险。这项研究目的是根据RF和ACPA状态，分析不同RA亚组风险方面吸烟与HLA-DRB1 SE间的相互作用。

根据是否存在RF和抗CCP2抗体，将偶发性RA病例（3645例，5883例匹配对照）分成4个亚组。通过使用logistic回归模型计算具有95％置信区间的比值比，确定每个RA亚组吸烟对疾病风险的影响。通过计算相互作用引起的归因比例，评估吸烟与HLA-DRB1 SE基因间的潜在相互作用。

在RF+/抗CCP2+亚组中，吸烟和HLA-DRB1 SE都产生了独立的疾病风险，并且两种风险因素间存在强烈的相互作用。在RF-/抗CCP2+亚组中，HLA-DRB1 SE导致RA风险升高，而吸烟的独立作用有限。然而，HLA-DRB1与吸烟存在显著的相互作用。在RF+/抗CCP2-亚组中，吸烟者的风险升高，存在HLA-DRB1 SE对其有轻微影响，未观察到有相互作用。在RF-/抗CCP2-亚组中，吸烟和HLA-DRB1 SE都没有增加疾病风险。

这项研究结果表明在4个血清学定义的RA亚组中，吸烟和HLA-DRB1有不同影响。

原始出处：

Anna Karin Hedstrom. Smoking, HLA‐genes and serology in rheumatoid arthritis; complex relationships investigated in the Swedish EIRA case‐control study. Arthritis Rheumatol. 11 February 2019.

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2019-12-07 wgsun

#HLA基因#

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2019-09-25 ms6390871039024434

#Arthritis#

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2019-02-22 lmm397

#关节炎#

25 0
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2019-02-22 ms4964546379600229

#类风湿#

26 0
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2019-02-22 zhaojie88

#ART#

37 0
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2019-02-22 jjjiang0201

#血清学#

43 0
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2019-02-22 ms1467340776200723

#风湿性关节炎#

25 0
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2019-02-22 marongnuan

#HLA#

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