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Pain：联合使用苯二氮卓类与阿片类药物的风险增加！

2017-12-16 MedSci MedSci原创

苯二氮卓类阿片类风险
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苯二氮卓类药物和阿片类药物通常用于患有精神疾病和疼痛的退伍军人中。近期，一项发表在杂志Pain上的研究旨在确定相伴使用苯二氮卓类－阿片类增加是否会发生超过非急性阿片类药物使用基线风险的不利结果的发生。此项研究包含了2008年至2012年期间至少需要一项阿片类处方的所有退伍军人。非急性阿片类药物的使用被定义为在60天内具有大于或等于20天的阿片类药物处方。相伴使用被定义为重叠使用至少七天的阿片样物质

苯二氮卓类药物和阿片类药物通常用于患有精神疾病和疼痛的退伍军人中。近期，一项发表在杂志Pain上的研究旨在确定相伴使用苯二氮卓类－阿片类增加是否会发生超过非急性阿片类药物使用基线风险的不利结果的发生。此项研究包含了2008年至2012年期间至少需要一项阿片类处方的所有退伍军人。非急性阿片类药物的使用被定义为在60天内具有大于或等于20天的阿片类药物处方。相伴使用被定义为重叠使用至少七天的阿片样物质和苯并二氮卓类药物处方。只使用非急性阿片类药物的使用者根据倾向评分与相伴阿片类药物苯二氮卓类药物使用者匹配。 共有365天的观察期以识别不良结果。主要结果为检查了以下一种或多种结果的存在：与阿片类药物有关的事故和过量剂量，与酒精和非阿片类药物有关的事故和过量剂量，自残伤害，暴力伤害，总体伤口/和死亡。使用调整回归控制Logistic倾向评分分析相伴使用与不良结果之间的关联。最终的匹配样本包括396,141名仅使用非急性阿片类药物的退伍军人的和48,971名相伴使用苯二氮卓类阿片类药物者。相伴接受阿片类药物和苯二氮卓药物增加了发生不良后果的风险，比值比为1.359（95％CI：1.320-1.4

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    2017-12-18 10518093zz

    #阿片类药物#

    0

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    2017-12-18 lhlxtx

    #阿片类#

    0

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    2017-12-18 海豹

    #苯二氮卓类#

    0

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    2017-12-16 戒馋，懒，贪

    谢谢分享学习了

    0

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    2017-12-16 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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