Nature:研究人员识别重要的信号分子β-arrestins

2016-03-31 佚名 渐冻人尘雾

在最新发表于《Nature》期刊的研究中,一个国际科学家团队在一种"信号分子"的研究工作中获得了新的见解,将为该领域的药物(比如止痛药)提供新的策略。 该研究由德国维尔茨堡大学(University Würzburg)和英国格拉斯哥大学(University of Glasgow)的科学家们领导,发现β-arrestins是由G蛋白偶联受体(GPCRs)激活的独立信号分子。 GPCR

在最新发表于《Nature》期刊的研究中,一个国际科学家团队在一种"信号分子"的研究工作中获得了新的见解,将为该领域的药物(比如止痛药)提供新的策略。

该研究由德国维尔茨堡大学(University Würzburg)和英国格拉斯哥大学(University of Glasgow)的科学家们领导,发现β-arrestins是由G蛋白偶联受体(GPCRs)激活的独立信号分子。

GPCR是药物研究最重要的靶点,对细胞通讯(包括疼痛过程和感官知觉)是至关重要的。作为许多疗法药物的分子靶点,GPCR有能力在细胞内经由G蛋白传输编码在荷尔蒙和神经递质中的信息,而β-arrestins被认为能够阻断这些过程。

由于它们的多样性,GPCRs和G蛋白信号是疗法药物的重要靶点,但有时会产生有害的副作用。通过开发经由β-arrestins而非G蛋白的能够促进信号传递的分子,有可能克服这些问题。这项新研究表明,这可能是强效止痛药长期疗法的重大进展。

在分子水平特定激活β-arrestins的新药物,可能将身体出现的耐药性和患者感受的副作用最小化,从而成为更有效的长期疗法。

格拉斯哥大学分子细胞和系统生物学研究所Graeme Milligan教授说:"对β-arrestins在信号中作用的新见解,开启了设计新型药物和改进药物的新图景,涉及从痴呆到糖尿病的(广泛)领域。格拉斯哥大学已经着手迎接这种挑战。"

该研究另一位作者Andrew Tobin教授目前在莱斯特大学医学研究委员会毒理学单元(MRC Toxicology Unit)工作,他将在2016年夏天来到格拉斯哥大学与Milligan教授及其他人继续进行这项工作。

维尔茨堡大学药理学教授Martin J Lohse说:"当我在1990年发现β-arrestin时,它看起来具有阻断受体的功能。使用最新的技术,我们才得以证明它作为独立的信号分子发挥作用。"

在另一篇同一天发表于《Nature》的研究中,美国研究团队使用不同的技术获得了类似的结论。

欧洲论文表明,β-Arrestin被受体激活到活跃状态,这种活跃状态在与受体相互作用后会持续更长的时间。这种改变是如此显着,使β-Arrestin的激活和失活循环过程可以被探测到--定义独立信号分子的标准。

原始出处:

Susanne Nuber,Ulrike Zabel,Kristina Lorenz,et al.β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.Nature.31 March 2016.

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    2016-08-17 liye789132251
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    2016-05-22 xsm918
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    2016-11-16 changhe713
  6. [GetPortalCommentsPageByObjectIdResponse(id=1880981, encodeId=d0131880981a2, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Aug 17 14:27:00 CST 2016, time=2016-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050540, encodeId=dec1205054061, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Mon Jul 04 10:27:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795728, encodeId=e4551e957284f, content=<a href='/topic/show?id=c9d61e46874' target=_blank style='color:#2F92EE;'>#TINs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17468, encryptionId=c9d61e46874, topicName=TINs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=49cf452, createdName=xsm918, createdTime=Sun May 22 02:27:00 CST 2016, time=2016-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907449, encodeId=1f3f190e449e3, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Thu Feb 23 16:27:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780025, encodeId=62431e80025e6, content=<a href='/topic/show?id=3cf02e78e3' target=_blank style='color:#2F92EE;'>#Arrest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2778, encryptionId=3cf02e78e3, topicName=Arrest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Wed Nov 16 19:27:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75009, encodeId=7070e5009be, content=新发现啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Thu Mar 31 12:44:00 CST 2016, time=2016-03-31, status=1, ipAttribution=)]
    2016-03-31 milkshark

    新发现啊

    0