Am J Kidney Dis:肥胖对腹膜透析患者寿命、残肾功能、腹膜炎和生存率的影响!

2017-12-10 xing.T MedSci原创

由此可见,肥胖的PD患者比不肥胖的PD患者发生并发症的风险更高,他们的生存率并不劣于匹配的HD患者。

严重肥胖通常被认为是腹膜透析(PD)的禁忌症,其患病率随着时间的推移而增加。然而,在美国人群中,PD患者的死亡率比血液透析(HD)患者的死亡率下降得更快。在当今时代,终末期肾病患者肥胖与临床结局之间的关系尚不清楚。近日,肾脏病领域权威杂志Am J Kidney Dis上针对这一问题发表了一篇研究文章。

该研究采用历史队列研究,参与者为15573名PD患者。研究指标为体重指数(BMI),结局包括受试者寿命、残余肾肌酐清除率、腹膜炎和生存率。

研究人员发现较高的BMI与转移到HD治疗的时间较短(P<0.001),进行肾移植的时间较长(P<0.001),腹膜炎相关的住院更加频繁(P=0.05)。与体瘦患者相比,肥胖患者的残余肾功能下降更快(P<0.001)。此外,BMI与死亡率之间有一个U型的关联,生存率最大的BMI范围为30-35kg/m2之间。与匹配的HD患者相比,PD患者BMI在<25和25-35kg/m2之间有较低的死亡率,在BMI≥35kg/m2时具有等效的生存率(交互作用P=0.001[与<25kg/m2进行比较])。严重肥胖患者的生存差异的减少只在糖尿病患者中观察到,而在那些没有糖尿病的患者未观察。

由此可见,肥胖的PD患者比不肥胖的PD患者发生并发症的风险更高,他们的生存率并不劣于匹配的HD患者。

原始出处:

Yoshitsugu Obi,et al. Impact of Obesity on Modality Longevity, Residual Kidney Function, Peritonitis, and Survival Among Incident Peritoneal Dialysis Patients. Am J Kidney Dis.2017. http://dx.doi.org/10.1053/j.ajkd.2017.09.010

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    2018-11-12 yese
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    2017-12-12 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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  5. 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  7. 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  8. 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    2017-12-12 gwc389
  9. 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    2017-12-12 xuyong530
  10. 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    2017-12-10 天涯183

    非常好的文章.学习了

    0

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