Sci Signal：IL-2信号通路对自身免疫疾病的影响

2017-12-27 药明康德学术经纬

调节性T细胞 (regulatory T cells， Treg) 能够抑制对自体产生反应的效应T细胞，从而防止诸如1型糖尿病这类自身免疫疾病的产生。而白细胞介素-2 (interleukin-2， IL-2) 对Treg细胞不同亚型的发育和在体内的动态平衡非常重要。

调节性T细胞 (regulatory T cells， Treg) 能够抑制对自体产生反应的效应T细胞，从而防止诸如1型糖尿病这类自身免疫疾病的产生。而白细胞介素-2 (interleukin-2， IL-2) 对Treg细胞不同亚型的发育和在体内的动态平衡非常重要。编码 IL-2和它的受体的基因上出现的变异与自身免疫疾病的风险相关。为了研究IL-2信号通路对自身免疫疾病的影响，迈阿密大学 (University of Miami) 的研究人员在Treg细胞中表达了一种IL-2受体β亚基的突变体，这种突变受体亚基能够将IL-2信号强度降低2~3倍。研究人员发现，在1型糖尿病的小鼠模型中，如果将在Treg细胞中的IL-2信号通路强度降低，小鼠将更早出现糖尿病症状。同时，这些小鼠体内不同Treg细胞亚型的数目和活性下降，而自身反应效应T细胞会入侵胰脏。

这项研究表明在自身免疫疾病中使用低剂量的IL-2来调节不同Treg细胞亚型可能是值得研究的医疗策略。

原始出处：

Connor J. Dwyer，et al.，Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice.Sci Signal.19 Dec 2017：Vol. 10， Issue 510， eaam9563.

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2018-04-11 yaanren

#Signal#

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2018-01-01 楚秀娟

#Sign#

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2018-10-20 soongzhihua

#自身免疫疾#

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2017-12-29 晓辰

#免疫疾病#

37 0
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2017-12-29 智者为医08

#信号通路#

29 0
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2017-12-29 gao_jian4223

#自身免疫疾病#

35 0
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2017-12-29 tomyang93

#IL-2#

39 0
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2017-12-28 Jackie Li

学习

75 0

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