Dig Liver Dis: 高分化胰腺神经内分泌肿瘤的大小与Ki67增殖指数相关

2019-05-21 不详 MedSci原创

对于年轻患者和术前Ki67增殖指数≥3%的分化良好的非功能性小胰腺神经内分泌肿瘤(NF-PanNET)的保守治疗效果并不是十分理想。本项研究的目的是评估根治性切除术的散发性NF-PanNET患者的年龄,肿瘤大小和分级之间的关系。

背景
对于年轻患者和术前Ki67增殖指数≥3%的分化良好的非功能性小胰腺神经内分泌肿瘤(NF-PanNET)的保守治疗效果并不是十分理想。本项研究的目的是评估根治性切除术的散发性NF-PanNET患者的年龄,肿瘤大小和分级之间的关系。

方法
研究人员回顾性分析了接受散发性NF-PanNET(不包括G3)手术的患者。进行线性回归分析以评估连续变量之间可能的相关性,而进行多重逻辑回归分析以确定NF-PanNET-G2的预测因子。

结果
总体而言,本项研究纳入了235例NF-PanNET-G1 / G2患者。中值最大直径为25毫米。年龄与肿瘤大小(P= 0.675)和Ki67指数(P= 0.376)无关。在多元线性回归分析中,与Ki67指数独立相关的因素是NF-PanNET大小(P= 0.031),神经周围浸润(P= 0.004),微血管侵犯(P= 0.001)和坏死(P= 0.009)。用于预测NF-PanNET-G2的最准确的NF-PanNET尺寸为25 mm。在多变量分析中,NF-PanNET大小> 25 mm与PanNET-G2的风险独立相关(P= 0.025)。

结论
年龄与NF-PanNET大小不存在相关性,而增殖指数与NF-PanNET大小之间存在相关性。

原始出处:

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    2020-04-07 gwc392
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    2020-01-30 gds2009
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