Hypertension:早产孕妇30年后心血管疾病风险如何?

2020-02-04 xing.T MedSci原创

由此可见,研究人员得出的结论表明妊娠期间的血管疾病,特别是先兆子痫,可以解释早产与未来孕妇心血管疾病住院之间四分之一的关联。

早产的妇女有患心血管疾病的风险,但这一关联的原因尚不清楚。近日,心血管权威杂志Hypertension上发表了一篇研究文章。研究人员旨在明确妊娠期间血管疾病是否可以解释早产与未来孕妇心血管疾病之间的关系。

研究人员分析了1989年至2017年在魁北克的1199364名孕妇的纵向队列研究,并随访了19186983人次每年。研究人员计算了心肌梗塞、缺血性卒中和其他心血管疾病的住院率。研究人员使用多变量Cox回归来估算调整过的风险比和95%CI,用于评估极早和中度早产与孕妇心血管疾病住院之间的关联。研究人员确定了由于先兆子痫、分娩时的急性心脏事件、产前/产后出血和心脏缺陷引起的关联的比例。

与足月分娩(每10000人中26.2人)相比,极早(每10000人年43.7人)和中度(每10000人中39.4人)的产妇心血管住院发生率更高。极早产非常危险,其心血管住院风险为1.67倍(95%CI为1.56–1.79),中度早产风险为1.51(95%CI为1.46-1.56)。妊娠期间的血管疾病解释了极早产26.2%和中度早产24.0%与心血管病住院之间的关联。先兆子痫是这些因素的最大贡献者。

由此可见,研究人员得出的结论表明妊娠期间的血管疾病,特别是先兆子痫,可以解释早产与未来孕妇心血管疾病住院之间四分之一的关联。

原始出处:

Insight From Cardiac Magnetic Resonance Imaging.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14310

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