J Endod:根尖周炎伴随意外根穿孔的发育成熟牙齿的异体细胞疗法:一例病例汇报

2020-06-30 lishiting MedSci原创

细胞疗法是牙髓再生疗法的一种备选方案。这篇病例汇报的目的是为了描述使用包裹异体脐带血间充质干细胞(UC-MSCs)的生物支架治疗一例根尖周炎伴随意外根穿孔的发育成熟牙齿的病例。

细胞疗法是牙髓再生疗法的一种备选方案,为复杂牙髓病例的一种经典治疗策略。这篇病例汇报的目的是为了描述使用包裹异体脐带血间充质干细胞(UC-MSCs)的生物支架治疗一例根尖周炎伴随意外根穿孔的发育成熟牙齿的病例。

1位19岁经历正畸治疗的健康男性tooth #7需要牙髓治疗,在之前的治疗过程中诊断为根尖周炎伴随根颈1/3的意外穿孔。牙根穿孔以玻璃离子和复合树脂充填,根管预备、消毒并封氢氧化钙。3周后,将异体UC-MSCs包裹于去血小板血浆,随后植入至根管内并采用Biodentine (Septodont, Saint-Maur-des-Fosses, France)置于釉牙骨质界下。最后,牙齿采用复合树脂充填。

术后6个月和1年进行随访。检测包括根尖X线片,CBCT,敏感度和活力测试。X线和CBCT影像结果显示,根尖阴影消失。临床评估表明,扪诊和叩诊正常;牙齿的牙髓电活力测试有反应,并且活力测试呈现为低血流注单位。

结论:这篇病例报告表明,包裹异体UC-MSCs去血小板血浆支架对于治疗根尖周炎伴随意外根穿孔的恒牙具有一定的潜力。

原始出处:

Claudia Brizuela Cordero, Gaston Meza Santander, et al. Allogeneic Cellular Therapy in a Mature Tooth With Apical Periodontitis and Accidental Root Perforation: A Case Report. J Endod., 2020 Jun 9;S0099-2399(20)30269-7. doi: 10.1016/j.joen.2020.04.007.

 

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