Stroke:胰高血糖素样肽1受体激动剂与卒中预防

2019-12-09 xing.T MedSci原创

由此可见,胰高血糖素样肽1受体激动剂可降低T2D患者非致命性卒中的风险。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在对心血管结局试验(CVOTs)进行荟萃分析,以评估胰高血糖素样肽1受体激动剂治疗在降低2型糖尿病患者卒中风险中的作用。

研究人员检索了Pubmed和其他电子数据库,检索时间截止至2019年6月20日,以确定相关的研究。在汇总所有试验的数据后,研究人员使用具有95%CI的风险比来衡量胰高血糖素样肽1受体激动剂与卒中风险之间的关联。

研究人员确定了7例CVOTs,共有56004名参与者。在2型糖尿病患者中使用胰高血糖素样肽1受体激动剂可使非致命性卒中的风险降低15%(P=0.002),致命性卒中的风险降低19%(P=0.150),整体卒中风险降低了16%(P=0.001)。血红蛋白A1c水平降低或体重降低与卒中风险之间没有关联。

由此可见,胰高血糖素样肽1受体激动剂可降低T2D患者非致命性卒中的风险。 

原始出处:

Giuseppe Bellastella.et al.Glucagon-Like Peptide-1 Receptor Agonists and Prevention of Stroke Systematic Review of Cardiovascular Outcome Trials With Meta-Analysis.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.027557

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    2019-12-11 hbwxf
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    2019-12-10 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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