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Oncotarget：抗乳腺癌，苯乙双胍挑战"一哥"二甲双胍！

2017-08-19 Emma MedSci原创

苯乙双胍乳腺癌抗癌
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大量研究证实二甲双胍不仅控糖有效，还可以适度减重，降低心血管并发症与死亡风险，并且安全性良好，此外研究还提示二甲双胍（通常规定的抗2型糖尿病药物）与降低癌症风险（包括前列腺癌，肺癌，胰腺癌和乳腺癌）相关。

大量研究证实二甲双胍不仅控糖有效，还可以适度减重，降低心血管并发症与死亡风险，并且安全性良好，此外研究还提示二甲双胍（通常规定的抗2型糖尿病药物）与降低癌症风险（包括前列腺癌，肺癌，胰腺癌和乳腺癌）相关。二甲双胍介导的抗癌活动与全身和细胞调节活性有关，包括降低胰岛素水平，增加胰岛素敏感性，AMP活化蛋白激酶（AMPK）/哺乳动物靶标雷帕霉素（mTOR）的抑制作用，似乎二甲双胍诱导的胰岛素受体（IR）和胰岛素生长因子（IGF）受体（IGFR）失活也刺激调节网络，而苯乙双胍（phenformin）是一种与二甲双胍具有类似功能的更具生物效益的双胍，关于其的抗癌研究仍然不多。

发表于Oncotarget的一篇文章中，研究人员使用ErbB2过表达乳腺癌细胞和动物模型来测试苯乙双胍的抗癌潜力。研究结果显示，苯乙双胍介导的IGF1/IGF1R调节可作为潜在的抗癌机制，并为继续开发苯乙双胍和其他双胍作为乳腺癌治疗药物提供了支持。

苯乙双胍（25-75μM）在SKBR3和78617乳腺癌细胞中降低细胞增殖和损害细胞周期进程。苯乙双胍治疗后减少肿瘤大小（30 mg/kg/d）。在MMTV-ErbB2转基因小鼠同基因肿瘤模型中这一结果也得到了证实。在ErbB2过表达的乳腺癌细胞和小鼠乳腺肿瘤来源的组织中，苯乙双胍还阻断上皮-间质转化，降低侵袭性表型，抑制受体酪氨酸激酶信号传导（包括胰岛素受体底物1和IGF1R）。此外，在体外研究中苯乙双胍抑制IGF1刺激的增殖，受体酪氨酸激酶信号传导和上皮-间质转化标志物。

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    2018-03-10 仁医06

    #target#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1795443, encodeId=35251e9544396, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Mar 10 10:21:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235554, encodeId=c7c123555416, content=文章很好，赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Aug 21 06:33:25 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235358, encodeId=3da2235358f5, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Sun Aug 20 09:57:56 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235322, encodeId=fcd623532264, content=学习了，好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Aug 20 08:12:57 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235282, encodeId=ae3a235282d2, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 20 07:00:12 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235257, encodeId=a7f023525ec6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Aug 20 06:37:20 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235240, encodeId=a755235240f9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Aug 20 06:28:29 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-21 1e10c84am36(暂无匿称)

    文章很好，赞赞赞

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1795443, encodeId=35251e9544396, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Mar 10 10:21:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235554, encodeId=c7c123555416, content=文章很好，赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Aug 21 06:33:25 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235358, encodeId=3da2235358f5, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Sun Aug 20 09:57:56 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235322, encodeId=fcd623532264, content=学习了，好东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Sun Aug 20 08:12:57 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235282, encodeId=ae3a235282d2, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Aug 20 07:00:12 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235257, encodeId=a7f023525ec6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Aug 20 06:37:20 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235240, encodeId=a755235240f9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Aug 20 06:28:29 CST 2017, time=2017-08-20, status=1, ipAttribution=)]
    2017-08-20 lietome24

    不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！

    0

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    2017-08-20 戒馋，懒，贪

    学习了，好东西

    0

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    2017-08-20 清风拂面

    学习了，谢谢分享

    0

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    2017-08-20 1e17414fm02(暂无匿称)

    学习

    0

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    2017-08-20 130****4638

    学习了受益匪浅

    0