精品指南:人感染H7N9禽流感诊疗方案(2017年第1版)要点解析

2017-05-16 MedSci MedSci原创

国家卫生计生委办公厅日前制定《人感染H7N9禽流感诊疗方案(2017年第一版)》(以下简称新版《诊疗方案》)。新版《诊疗方案》要求,提升医务人员对人感染H7N9禽流感早期识别、诊断与治疗的能力;坚持“早发现、早报告、早诊断、早治疗”原则,提高对疑似病例的警惕性,对流感样病例在进行抗病毒治疗前采集标本进行检测,并及早进行抗病毒治疗。梅斯小编整理了人感染H7N9禽流感诊疗方案(2017年第1版)的要点


国家卫生计生委办公厅日前制定《人感染H7N9禽流感诊疗方案(2017年第一版)》(以下简称新版《诊疗方案》)。新版《诊疗方案》要求,提升医务人员对人感染H7N9禽流感早期识别、诊断与治疗的能力;坚持“早发现、早报告、早诊断、早治疗”原则,提高对疑似病例的警惕性,对流感样病例在进行抗病毒治疗前采集标本进行检测,并及早进行抗病毒治疗。梅斯小编整理了人感染H7N9禽流感诊疗方案(2017年第1版)的要点分析及解读,供大家参考!
一、新版方案的要点内容:
(1)和旧版方案相比,新版《诊疗方案》有以下要点变化:
1.概述:人感染H7N9禽流感是由甲型H7N9禽流感病毒感染引起的急性呼吸道传染病,其中重症肺炎病例常可合并ARDS(急性呼吸窘迫综合征)、脓毒性休克,甚至多器官功能衰竭。
2.病原学:病原学部分将甲型流感病毒亚型做了更新,补充说明了新近发现的禽流感病毒亚型,而且强调H7N9禽流感病毒对禽类致病力低、不易被发现的特点。 
3.流行病学:传染源:携带H7N9禽流感病毒的禽类。目前,大部分为散发病例,有数个家庭聚集性发病病例,尚无持续性人际传播的证据,应警惕医院感染的发生。
4.临床表现:潜伏期:多为7天以内,也可长达10天。
(2)对疑似人感染H7N9禽流感病例,要尽可能留取下呼吸道标本并送检。 
1.病原学及相关检测:采集呼吸道标本(如鼻咽分泌物、痰、气道吸出物、支气管肺泡灌洗液)送检,下呼吸道标本检测阳性率高于上呼吸道标本。标本留取后应及时送检。
2.病原学检测:首选核酸检测;甲型流感病毒通用型抗原检测:呼吸道标本甲型流感病毒通用型抗原快速检测H7N9禽流感病毒阳性率低;对于高度怀疑人感染H7N9禽流感病例,应尽快对送检的呼吸道标本进行核酸检测;血清学检测:动态检测急性期和恢复期双份血清H7N9禽流感病毒特异性抗体水平呈4倍以上升高。
3.预后:重症患者预后差;影响预后的因素可能包括患者的年龄、基础疾病、并发症等。目前报告的病例虽然大部分有活禽或活禽市场暴露史,但部分病例并无明确的暴露史。因此,对发病前10天有H7N9禽流感疫情地居住或旅行史、出现流感样症状的病例,也要警惕人感染H7N9禽流感的可能。
4.流行病学史:发病前10天有接触禽类及其分泌物、排泄物,或者到过活禽市场,或者与人感染H7N9禽流感病例有密切接触史。
5.重症病例诊断:符合下列1项主要标准者,或≥3项次要标准者,可被诊断为重症病例。主要标准:需要气管插管行机械通气治疗;脓毒性休克经积极液体复苏后仍需要血管活性药物治疗;次要标准:呼吸频率≥30次/分;氧合指数≤250毫米汞柱(1毫米汞柱=0.133千帕);多肺叶浸润;意识障碍和(或)定向障碍;血尿素氮≥7.14毫摩尔/升;收缩压<90毫米汞柱需要积极的体液复苏。
6.抗病毒药物使用原则:在使用抗病毒药物之前,宜留取呼吸道标本;抗病毒药物应尽早使用,无须等待病原学检测结果。奥司他韦使用要结合肾功能调整剂量,此外,在使用过程中要复查核酸,如果病例病情无好转或加重,要警惕耐药的可能。 
二、人感染H7N9禽流感诊疗方案(2017年第1版)原文

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    2018-02-18 hongbochen
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    2017-05-17 虈亣靌

    不错学习中,每天进步一点

    0

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GetPortalCommentsPageByObjectIdResponse(id=198858, encodeId=9ba819885848, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 16 16:54:07 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-17 cqykthl

    禽流感病毒真是太厉害了

    0

  7. 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    2017-05-17 杨利洪

    新旧对照,学习了

    0

  8. 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    2017-05-17 惠映实验室

    可以研究,有无新的发展

    0

  9. 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    2017-05-16 有备才能无患

    奥司他韦口服,尽早

    0

  10. 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    2017-05-16 吴教授

    学习了

    0

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