AGING CELL:晚年限时饮食和运动改变肥胖症的健康状况

2019-05-26 海北 MedSci原创

已有的证据显示,老龄化和肥胖会增加多发病和残疾的风险,因此,确定用于逆转健康状况下降的干预措施是公共卫生的重要优先事项。 从早年开始运动和限时喂养(TRF)有益于多种健康参数,但至今为止,在老年后开始采取这些措施的功效和安全性是不确定的。 最近,研究人员测试了运动与TRF对20至24个月大的饮食诱导的肥胖老年小鼠的影响。研究人员描述了跨越关键领域的健康跨度:身体成分,生理,代谢和心血管功能,日

已有的证据显示,老龄化和肥胖会增加多发病和残疾的风险,因此,确定用于逆转健康状况下降的干预措施是公共卫生的重要优先事项。

从早年开始运动和限时喂养(TRF)有益于多种健康参数,但至今为止,在老年后开始采取这些措施的功效和安全性是不确定的。

最近,研究人员测试了运动与TRF2024个月大的饮食诱导的肥胖老年小鼠的影响。研究人员描述了跨越关键领域的健康跨度:身体成分,生理,代谢和血管功能,日常生活活动(ADL)行为和病理学。

研究结果证明,运动和TRF都改善了身体成分的方方面面。运动独特地有益于身体功能,TRF独特地有益于新陈代谢,ADL行为和肝脏病理学的循环指标。

在运动小鼠中没有观察到不良结果,但相反,在TRF后观察到体重减轻和血管不适应。

通过综合利益和风险指数,研究人员得出结论,运动提供的净健康益处比TRF更多。因此,对肥胖的老年人进行推断,运动是改善健康状况的安全有效的选择,但在推荐TRF之前需要进行额外的综合研究。


原始出处:

Marissa J. Schafer et al. Late‐life time‐restricted feeding and exercise differentially alter healthspan in obesity. AGING CELL, 2019; doi: https://doi.org/10.1111/acel.12966


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