JACC Cardiovasc Inte:95%冠脉自发夹层1月内可自行愈合

2019-03-06 xujing 中国循环杂志

JACC心血管介入子刊杂志上的最新研究表明,大多数自发性冠状动脉夹层在30天后自发愈合。

JACC血管介入子刊杂志上的最新研究表明,大多数自发性冠状动脉夹层在30天后自发愈合。

尽管自发性冠状动脉夹层相对少见,但在中青年妇女中,它已日益被认为是急性冠脉综合征的重要原因。

研究者对156例急性自发性冠状动脉夹层患者(182个病变)进行前瞻性随访,并进行多次血管造影。排除接受经皮冠状动脉介入治疗的SCAD患者。

血管造影愈合标准需要满足以下三个标准:(1)血管造影狭窄改善,(2)残余狭窄<50%,(3)正常的TIMI-3血流。

本组患者平均年龄51.5岁,女性88.5%,肌纤维发育不良75.6%。所有患者均出现心肌梗死(MI)。

在指数血管造影中,最常见的是2型自发性冠状动脉夹层(126/182个病变;69.2%),85个病变(46.7%)出现低于TIMI 3级血流,病变狭窄的中位数为79.0%。

研究人员发现,大多数(86.3%)自发性冠状动脉夹层都是通过保守治疗而自发愈合的,但存在时间依赖关系。

对于11.5%不符合血管造影愈合标准的病变,多是在事件后早期进行血管造影,其中73%源于复发性心肌梗死或复发症状。在自发性冠状动脉夹层事件后不到30天的重复血管造影中,只有约23%显示血管造影愈合,而95%的病变在30天以后显示血管造影愈合。

研究者指出,在没有血管成形术或支架植的情况下,随着壁内血肿的逐渐吸收和内膜瓣贴附在更深的动脉壁上,自发性冠状动脉夹层会自发愈合。

研究没有确定预测自发性冠状动脉夹层病变自发愈合的血管造影特征,如病变长度、狭窄程度和自发性冠状动脉夹层血管造影亚型。唯一临床特征差异是未愈合病变患者的射血分数更差,他们早期接受重复血管造影。

原始出处:
Saber Hassan, et al. Natural History of Spontaneous Coronary Artery Dissection With Spontaneous Angiographic Healing. JACC Cardiov Int. Published online February 27, 2019.

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    2019-05-10 hbwxf
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    2019-03-25 一天没事干

    很好的学习机会

    0

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    2019-04-10 quxin068
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