Pediatr Res:严重的早产儿视网膜病变与小脑和脑干体积缩小和神经发育缺陷有关!

2018-01-15 cuiguizhong MedSci原创

荷兰乌得勒支乌得勒支大学医学中心和乌得勒支大学新生儿科的Drost FJ近日在Pediatr Res杂志上发表了一篇文章,他们研究了严重早产儿视网膜病变(ROP)、脑部形态测量(TEA)与神经发育之间的关系。

荷兰乌得勒支乌得勒支大学医学中心和乌得勒支大学新生儿科的Drost FJ近日在Pediatr Res杂志上发表了一篇文章,他们研究了严重早产儿视网膜病变(ROP)、脑部形态测量(TEA)与神经发育之间的关系。

共有18例重度ROP患儿纳入本次回顾性病例对照研究。他们中位胎龄(GA)为25.3周,范围从24.6-25.9周。每名婴儿与2名对照的极度早产儿(n = 36)作为一个组,对出生体重、性别和脑损伤等进行研究。通过3T磁共振成像(TEA)的方法获得T2加权图像,使用自动分割方法计算脑体积,提取皮质折叠指数,分别在15和24个月时对神经发育进行评估。

结果他们发现,与相应的对照组相比,严重早产儿视网膜病变的患儿小脑体积较小(21.4±3.2比23.1±2.6 ml; P = 0.04),脑干体积也较小(5.4±0.5 ml比5.8±0.5 ml; P = 0.01)。此外,ROP患者在15个月时的发育系数(Griffiths Mental Development Scale)也显着降低(93±15对102±10; P = 0.01)。根据贝利量表(第三版),发现在24个月是,严重早产儿视网膜病变患儿的精细运动评分较低(10±3对12±2; P = 0.02)。

因此,他们认为,严重早产儿视网膜病变与小脑和脑干体积较小有关,早期神经发育较差。为进一步探索,需要通过儿童时期的后续研究来评估这项调查结果的长期影响。

原文出处:

Drost, F.J., et al., Severe retinopathy of prematurity is associated with reduced cerebellar and brainstem volumes at term and neurodevelopmental deficits at two years. Pediatr Res, 2018.

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    2018-09-24 feather89
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    2018-01-17 zutt
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    2018-01-17 neurowu
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    2018-01-16 三生有幸9135

    学习一下谢谢分享

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