Hypertension:睡眠呼吸暂停的表型和风险负担

2019-08-26 xing.T MedSci原创

总之,SA在中年普通人群中非常普遍。然而,即使是轻度SA患者显示出明显更高的代谢、炎症和心血管危险因素负担,并可能对公共健康产生影响。

睡眠呼吸暂停(SA)患病率增加。由于与医疗相关的成本和不良结局,社会经济负担很沉重,特别是在中度至重度SA患者中。然而,人群影响尚不清楚,特别是对于轻度SA患者。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估一般人群中SA的当前患病率和与SA相关的心血管风险。

研究人员对来自基于人群队列中的2205名符合条件的受试者中进行了家庭记录和广泛的临床、社会人口学和心血管评估。

1809名受试者成功获得了记录数据(平均年龄为56.0岁;标准差为5.9岁; 52.3%为女性)。男性轻度、中度和重度SA患病率分别为41.0%、11.8%和6.5%,女性患病率为26.6%、4.4%和1.2%。男性、年龄、增加的BMI和打鼾与SA独立相关,而嗜睡或疲倦则不然。与没有SA的患者相比,轻度SA与糖尿病(年龄和性别调整OR和95%CI为2.40; 1.52-3.80)、高血压(1.76; 1.42-2.19)、左心室肥大(1.36; 1.03-1.79)、动脉斑块(1.19; 0.94-1.52)和IL-6(白细胞介素-6)水平升高(1.37; 1.10-1.72)相关。这些关联在中度至重度SA患者中更为明显。

总之,SA在中年普通人群中非常普遍。然而,即使是轻度SA患者显示出明显更高的代谢、炎症和心血管危险因素负担,并可能对公共健康产生影响。 

原始出处:

Fré A. Bauters.et al.Phenotype and Risk Burden of Sleep Apnea A Population-Based Cohort Study.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13452

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    2019-08-28 tastas
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    2019-08-26 qingfengqishi5

    学习了,学习了

    0

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由此可见,在未治疗的严重OSA的老年患者中,卒中发生率而非冠心病发病率有所增加。适当的CPAP治疗可以降低这种风险。

Am J Respir Crit Care:新方法可有效治疗睡眠呼吸困难

美国科学家日前进行的一项研究显示,一种广为人知的可调节饥饿和体重的激素,可通过鼻腔给药的方式缓解睡眠过程中出现的呼吸问题。