Hypertension:孕期暴露在PM2.5污染的空气中,子代儿童期血压升高风险增加

2018-05-16 MedSci MedSci原创

暴露在空气污染的环境中,成人和儿童血压(BP)升高的风险都会增加。近期有证据表明孕期空气污染暴露可能会增加下一代的风险;但是,少有研究证实这一关系。Mingyu Zhang等人对Boston出生队列的1293位母亲(于1998-2012年招募)及其在3-9岁期间接受随访的有完整暴露和预后数据的子女进行前瞻性研究。主要暴露:孕期外界PM≤2.5μm (PM2.5)的浓度(通过将母亲住址与US缓解保护

暴露在空气污染的环境中,成人和儿童血压(BP)升高的风险都会增加。近期有证据表明孕期空气污染暴露可能会增加下一代的风险;但是,少有研究证实这一关系。

Mingyu Zhang等人对Boston出生队列的1293位母亲(于1998-2012年招募)及其在3-9岁期间接受随访的有完整暴露和预后数据的子女进行前瞻性研究。

主要暴露:孕期外界PM≤2.5μm (PM2.5)的浓度(通过将母亲住址与US缓解保护机构的空气质量监测匹配估算)。主要评估指标:儿童收缩压(SBP)百分位和血压升高(SBP≥90百分位)。

结果显示晚期妊娠空气PM2.5≥13μg/m3时,子代SBP百分位和血压升高风险急剧升高。晚期妊娠PM2.5暴露的最大三分位对比最低三分位,可使儿童SBP百分位增加4.85(95% CI 1.38-8.37)、血压升高风险增加1.61倍(95% CI 1.13-2.30)。晚期妊娠空气PM2.5每增加5μg/m3,儿童SBP百分位增加3.49(95% CI 0.71–6.26)、血压升高风险增加1.47倍(95% CI 1.17-1.85)。

本研究表明晚期妊娠暴露在外界PM2.5污染与子代3-9岁时的血压升高相关。

原始出处:

Mingyu Zhang,et al.Maternal Exposure to Ambient Particulate Matter ≤2.5 μm During Pregnancy and the Risk for High Blood Pressure in Childhood.Hypertension. May 15,2018.https://doi.org/10.1161/HYPERTENSIONAHA.117.10944

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    2018-07-03 楚钟
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createdBy=e32134104358, createdName=楚钟, createdTime=Tue Jul 03 02:35:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862063, encodeId=72681862063aa, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Sat Nov 03 01:35:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038898, encodeId=bec520388989b, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed May 23 18:07:43 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264993, encodeId=3e8a12649935e, content=<a href='/topic/show?id=9574144034a' target=_blank style='color:#2F92EE;'>#PM2.5#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14403, encryptionId=9574144034a, topicName=PM2.5)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472602, encodeId=ec1f14e2602bf, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501288, encodeId=c5e51501288cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316054, encodeId=27c231605409, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 17 17:14:31 CST 2018, time=2018-05-17, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1718940, encodeId=51451e1894024, content=<a href='/topic/show?id=32b888935ca' target=_blank style='color:#2F92EE;'>#血压升高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88935, encryptionId=32b888935ca, topicName=血压升高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c86e32676392, createdName=zhang92571, createdTime=Fri Jan 04 20:35:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736258, encodeId=6f391e362588c, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Tue Jul 03 02:35:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862063, encodeId=72681862063aa, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Sat Nov 03 01:35:00 CST 2018, time=2018-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038898, encodeId=bec520388989b, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Apr 29 08:35:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727291, encodeId=a49c1e27291bf, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 09 16:35:00 CST 2018, time=2018-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317896, encodeId=0c7c31e89691, content=环境污染治理刻不容缓, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Wed May 23 18:07:43 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264993, encodeId=3e8a12649935e, content=<a href='/topic/show?id=9574144034a' target=_blank style='color:#2F92EE;'>#PM2.5#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14403, encryptionId=9574144034a, topicName=PM2.5)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472602, encodeId=ec1f14e2602bf, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501288, encodeId=c5e51501288cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316054, encodeId=27c231605409, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 17 17:14:31 CST 2018, time=2018-05-17, status=1, ipAttribution=)]
    2018-10-09 feather89
  6. 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href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501288, encodeId=c5e51501288cb, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Fri May 18 02:35:00 CST 2018, time=2018-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316054, encodeId=27c231605409, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu May 17 17:14:31 CST 2018, time=2018-05-17, status=1, ipAttribution=)]
    2018-05-23 易水河

    环境污染治理刻不容缓

    0

  7. 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  9. 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    2018-05-17 虈亣靌

    了解一下.谢谢分享!

    0

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J Abnorm Child Psychol:除了伤心肺,PM2.5还坏脑子

近期发表的一项来自美国的研究表明,空气污染物中的细微颗粒物质(PM2.5)高水平暴露后,人的大脑结构和神经活动也会受到损害。

Occup Environ Med:台湾研究称,PM2.5影响精子质量

研究者认为,鉴于空气污染的长久和普遍,PM2.5的小影响也可能造成大危害,从而导致生育问题。

PLOS ONE:上海在校儿童究竟暴露于多高的PM2.5?

上海市疾病预防控制中心/上海市预防医学研究所的研究人员进行了一项研究,目的是对儿童PM2.5(空气动力学直径小于2.5μm的颗粒物质)的暴露进行评估。

JAHA:国内学者揭示PM2.5暴露可增加高血压的发生风险!

本研究的目的旨在评估环境空气细颗粒物(PM2.5)的长期暴露对生育年龄成年人高血压的影响。本研究纳入了2010年至2015年39348119例生育年龄(20-49岁)的参与者,每个社区的空气PM2.5平均浓度通过基于卫星的空间统计模型来测量。分析结果发现,PM2.5浓度与高血压之间的相关性并不是呈线性的,阈值浓度为47.9μg/m3,每高于阈值10‐μg/m3,参与者的收缩压则增加0.569mmH

BMJ:PM2.5是重要的新生儿低体重风险因素

研究证实,交通空气污染会影响胎儿生长发育,PM2.5是重要的新生儿低体重风险因素