NEJM:Nivolumab一线用于IV期及复发性非小细胞肺癌

2017-06-22 zhangfan MedSci原创

对于PDL1表达水平超过5%的,晚期及进展性非小细胞肺癌患者,较化疗相比,Nivolumab治疗未延长患者的无进展生存期,但总生存期略优于化疗,患者的耐受性及不良事件率显著优于化疗

Nivolumab较多西紫杉醇可显著延长先前治疗失败的非小细胞肺癌患者的生存期。在近日公布的III期临床研究结果中,研究人员考察了PDL1阳性患者中Nivolumab作为一线非小细胞肺癌药物的治疗前景。

研究招募了未接受治疗的IV期或复发的非小细胞肺癌患者,患者的PDL1表达水平超过1%,患者随机接受Nivolumab(静脉注射,每次3mg/kg,每2周一次)或铂基础化疗(3周一次最多6轮),若化疗组患者疾病进展则交叉进入单抗组。主要终点是无进展生存期。

对于PDL1水平超过5%的患者(423人),Nivolumab组平均无进展生存期为4.2个月,化疗组为5.9个月(进展风险1.15,95%,CI,0.91-1.45,P=0.25);总生存期14.4个月vs 13.2个月 (死亡风险1.02; 95% CI, 0.80 -1.30)。在212名化疗组患者中,有128人 (60%)接受Nivolumab作为后续治疗。单抗组71%的患者出现不良事件,化疗组为92%。3级以上不良事件发生率单抗组为18%,化疗组为51%。

研究认为,对于PDL1表达水平超过5%的,晚期及进展性非小细胞肺癌患者,较化疗相比,Nivolumab治疗未延长患者的无进展生存期,但总生存期略优于化疗,患者的耐受性及不良事件率显著优于化疗。

原始出处:

David P. Carbone et al. First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer. N Engl J Med. June 22 2017.

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    2018-02-12 snf701207
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    2017-08-28 tamgche
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    2017-06-23 luominglian113

    学习了,谢谢分享

    0

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    2017-06-22 往日如昨

    学习了谢谢分享

    0

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    2017-06-22 1dd7a091m35(暂无匿称)

    学习了。。。。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1909638, encodeId=1dff190963854, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Aug 07 03:55:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1911858, encodeId=17a9191185873, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Mon Feb 12 11:55:00 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007868, encodeId=ac24200e86881, content=<a href='/topic/show?id=601512826f6' target=_blank style='color:#2F92EE;'>#NIV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12826, encryptionId=601512826f6, topicName=NIV)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Mon Aug 28 20:55:00 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2059623, encodeId=59f12059623ce, content=<a href='/topic/show?id=2cc599381bd' target=_blank style='color:#2F92EE;'>#非小细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99381, encryptionId=2cc599381bd, topicName=非小细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Mon Dec 04 15:55:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214439, encodeId=1cca214439fc, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri Jun 23 19:15:23 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213887, encodeId=ba4d21388efe, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Jun 22 11:28:11 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213884, encodeId=a897213884a3, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Thu Jun 22 10:46:19 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213842, encodeId=4e5b213842ee, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicUw7yoAI4gptl6B3VGw6WZJ0uC02gdsRKGWuUVO3YSn6iagP9laH8FZIo3kTr5Xb9ricn6kqveJVs6FOWPec9yClJFkTXHtxSA/0, createdBy=a44f1685526, createdName=drdentist, createdTime=Thu Jun 22 09:28:28 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213839, encodeId=ac4821383933, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu Jun 22 09:26:28 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 drdentist

    学习了,谢谢

    0

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    2017-06-22 执着追梦

    学习,谢谢分享

    0

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