Sci Trans Med:某些中草药成分可能增加肝癌风险

2017-10-19 佚名 medicalxpress

根据最近报告说,研究人员发现了广泛的证据表明中国传统中草药与亚洲肝癌的联系。


Maps showing prevalence of aristolochic acid related cancers around the world. Credit: A.W.T. Ng et al., Science Translational Medicine (2017)

根据最近报告说,研究人员发现了广泛的证据表明中国传统中草药与亚洲肝癌的联系。

科学转化医学杂志的报告说,研究结果表明,需要采取更强有力的措施来防止人们食用称为马兜铃酸(AA)的化学物质,这些化学物质来源于马兜铃属植物家族的木本葡萄藤。

这些酸可以在分娩期间所用的一些中药中发现,以防止寄生虫和促进愈合。

研究人员测试了在台湾医院储存的98例肝肿瘤,发现78%的患者表现出癌变“可能与化学物质接触”有关。

由于这些酸引起“定义明确的突变特征”,研究人员还研究了中国89例肝癌样本,发现47%的患者与该传统医学成分有关。

在越南,26个肿瘤研究中有5个是匹配(19%),其余五个来自东南亚其他国家(56%)。

与中医的联系在北美(209个肝癌研究中占5%)并不常见,230个人中有1.7个来自欧洲。

台湾于2003年禁止使用植物的草药制剂,发现马兜铃酸可引起肾衰竭和尿路癌。不过,无论是中国大陆还是台湾地区都没有彻底的禁令,“只有特定的植物,而不是任何含有AA或其衍生物的植物和产品受到管制”,消费者很难避免这种情况。

研究人员发现,台湾肝癌AA型相关突变患病率在禁令实施后并未下降。

这可能是因为在数据中癌症下降需要更多的时间,如同烟草相关的癌症一样,吸烟显示导致肺肿瘤。或者可能是人们继续通过仍含有它们的其他产品和草药混合物而暴露于这些酸。

原始出处:

Alvin W. T. Ng, Song Ling Poon, Mi Ni Huang, et.al. Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Science Translational Medicine  18 Oct 2017 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1656894, encodeId=6bb01656894a6, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Jul 19 04:10:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061677, encodeId=159c20616e7ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Apr 10 05:10:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754668, encodeId=73441e54668b3, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Oct 22 21:10:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608124, encodeId=0d351608124fd, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 21 04:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2018-07-19 bsmagic9140
  2. [GetPortalCommentsPageByObjectIdResponse(id=1656894, encodeId=6bb01656894a6, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Jul 19 04:10:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061677, encodeId=159c20616e7ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Apr 10 05:10:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754668, encodeId=73441e54668b3, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Oct 22 21:10:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608124, encodeId=0d351608124fd, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 21 04:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2018-04-10 sjq027
  3. [GetPortalCommentsPageByObjectIdResponse(id=1656894, encodeId=6bb01656894a6, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Jul 19 04:10:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061677, encodeId=159c20616e7ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Apr 10 05:10:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754668, encodeId=73441e54668b3, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Oct 22 21:10:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608124, encodeId=0d351608124fd, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 21 04:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-22 zll0637
  4. [GetPortalCommentsPageByObjectIdResponse(id=1656894, encodeId=6bb01656894a6, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Jul 19 04:10:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061677, encodeId=159c20616e7ac, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Apr 10 05:10:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754668, encodeId=73441e54668b3, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Sun Oct 22 21:10:00 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608124, encodeId=0d351608124fd, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 21 04:10:00 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 仁心济世

相关资讯

多篇文章深入解读中草药是否真的可以治疗多种疾病?(下)

中医药是我国的国粹和瑰宝,也是是开发治疗多种疾病新型疗法的“金矿”。据世界卫生组织统计,目前在全世界大约有40亿人在使用中草药治病,占世界总人口的80%,而且世卫组织推测,中草药的开发利用在未来的10年内将在世界上全面兴起。【6】Carcinogenesis:新加坡科研人员揭示中药阿可拉定或可成为耐药性前列腺癌新疗法doi:10.1093/carcin/bgv040国际知名肿瘤期刊《癌症发生》

Illumina与中国医学科学院药用植物研究所合作建立中草药参考基因库

中医中药历史悠久,现代中医药将现代医学与传统中医药疗法相结合,在疾病治疗、药物与保健品研发领域潜力巨大。中医药相关产品是东亚地区医药产业的重要组成部分,全球影响力逐年上升,药用产品及保健品的年销售额超过600亿美元。 然而,由于作为原料的中药材品种多样,且缺乏稳定一致的化学成分,保障相关产品的安全和有效性仍是一项艰巨的任务。

Science:植物类黄酮“联手”肠道微生物抵御流感病毒,中草药抗流感也许找到科学依据了!

今天,华盛顿大学医学院的研究人员在《科学》杂志发表了一项重磅研究,他们发现广泛存在于天然植物中的黄酮类化合物,经过肠道微生物的降解,产生的代谢物被吸收后,能够上调I型干扰素信号通路,进而增强机体抗病毒免疫反应!

中草药与化学药联用,请注意!

随着中草药的应用日趋广泛,与化学药联合应用的几率相当大。哈佛大学医学院1998年的调查显示,有672万美国人在使用西药同时,还服用植物药和大剂量维生素。

我国多种中草药有了“基因身份证”

10月10日,2017全国植物与健康峰会在重庆举行,来自全国各省市500多名专家学者围绕植物与大健康产业发展需求进行探讨。对于中药产业的规范与发展,专家们不约而同地提到用现代科技来帮助传统中药提升价值。

PLoS One:中草药可用于房颤患者缺血性卒中的预防

背景:在台湾中草药产品(CHPs)广泛用于心房颤动(AF)。研究者探讨CHPs在预防房颤患者缺血性脑卒中发生的影响。方法:纳入健康保险数据库中2000-2011年新诊断的台湾房颤患者。诊断为AF后7天内有/无CHPs药物治疗。临床终点为缺血性卒中。采用卡方检验、Fisher精确检验和t检验,检验中医药与非中医药组间的差异性。应用Cox比例风险回归模型评估两组缺血性卒中发生的风险。结果:311例患者