Gastroenterology:接受与承诺疗法用于缓解IBD患者心理压力

2018-11-20 zhangfan MedSci原创

研究认为,克罗恩病患者接受接受与承诺疗法干预可显著缓解压力症状,提高心理健康水平

临床中发现克罗恩病溃疡性结肠炎患者有较高水平的压力和心理负担。接受与承诺疗法(ACT)是一种心理干预,通过正念、接纳、认知解离、以自我为背景、明确价值和承诺行动等过程以及灵活多样的治疗技术,帮助来访者增强心理灵活性并减少压力。近日研究人员开展随机研究,考察ACT对减轻IBD患者心理压力的效果。

122名静止或稳定轻度活动性IBD患者参与研究,随机接受8周的ACT或对照治疗。在基线、8周以及治疗后20周进行患者临床、人口、疾病活动、心理、血液粪便数据收集,在基线和第20周采集患者头皮毛发以测量类固醇浓度。研究的主要终点为DASS-21评估的压力症状变化,次要终点包括压力、焦虑、抑郁、生活质量、疾病活动和皮质固醇浓度变化。

79名患者完成评估,ACT组患者8和20周分别有39%和45%的患者压力缓解,而对照组仅为8%和11%。ACT疗法可减轻感觉压力和抑郁,但不能降低焦虑感。意向分析显示组间全部4项生活质量差异不显著,但协议分析显示ACT可改善全部4项生活质量。研究期间,组间主客观疾病活动差异不显著。研究发现,毛发皮质固醇含量与基线压力和焦虑相关,但其变化与ACT治疗效果不相关。

研究认为,克罗恩病患者接受接受与承诺疗法干预可显著缓解压力症状,提高心理健康水平。

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    2019-04-25 许安
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    2018-11-22 bnurmamat
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