ECCO 2016:粪便微生物移植解决难治性溃疡性结肠炎

2016-04-05 Mechront 译 MedSci原创

欧洲克罗恩病和结肠炎会议上称,对难治性急性溃疡性结肠炎(UC)患者,通过结肠镜和灌肠进行粪便微生物移植(FMT),可有效的诱导患者的临床和内镜缓解。该研究纳入了81名对标准治疗无效的急性UC患者,在第1天随机通过结肠镜输注FMT或安慰剂,然后每周使用FMT或安慰剂灌肠5天,共计8周。研究者从3-7名不相关的捐赠者和停止使用糖皮质激素的患者处获取FMT。研究以第8周无激素临床缓解和内镜缓解或反应作为

欧洲克罗恩病和结肠炎会议上称,对难治性急性溃疡性结肠炎(UC)患者,通过结肠镜和灌肠进行粪便微生物移植(FMT),可有效的诱导患者的临床和内镜缓解。

该研究纳入了81名对标准治疗无效的急性UC患者,在第1天随机通过结肠镜输注FMT或安慰剂,然后每周使用FMT或安慰剂灌肠5天,共计8周。研究者从3-7名不相关的捐赠者和停止使用糖皮质激素的患者处获取FMT。研究以第8周无激素临床缓解和内镜缓解或反应作为复合主要终点;无激素临床缓解、临床反应、内镜缓解、内镜反应、生活质量和安全性作为次要终点。

数据显示,FMT组(n=41)和对照组(n=40)达到复合主要终点的患者分别为11(27%)和3名(8%)(P = .02)。FMT组达到无激素临床缓解(44% vs. 20%; P = .02)恶化临床反应(54% vs. 23%; P < .01)的比例更多;此外无激素内镜缓解和反应率分别为17% vs. 8% (P = .19)和37% vs. 10% (P < .01)。

不良事件发生情况在两组间差异不大,共有3例严重不良事件,对照组有1名患者、FMT组有2名患者出现结肠炎恶化,其中一名患者因为重度UC行了结肠切除术。

接受开放标签FMT的37名对照组患者中有27%的患者达到主要终点,46%达到临床缓解,24%达到内镜缓解。

研究者写道:“关于FMT最大的对照试验已经表明,对难治性急性UC患者进行多体系统结肠灌肠FMT,可有效诱导临床和内镜缓解。”

原始出处:

Paramsothy S, et al. Abstract OP017. Presented at: ECCO Congress; March 16-19, 2016. Amsterdam.

FMT induces remission in resistant ulcerative colitis.Healio.April 4, 2016

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    2016-11-13 nymo
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    2016-07-20 仁医06
  4. 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  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-08 hekzn

    受用了

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-08 jason刘)

    好好学医

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-07 freve
  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-07 Homburg
  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-06 dhzzm

    学习了,很好

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:20:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-06 yilibaisha

    高大上的理论与技术学习了

    0