Neurology:糖代谢异常可增加轻型卒中患者卒中再发的风险

2016-10-07 MedSci MedSci原创

目的:为了探讨葡萄糖调节异常是否增加轻型缺血性卒中或TIA患者新发卒中。方法:研究者从急性非致残性脑血管事件高危患者氯吡格雷试验中获得数据,轻型卒中或TIA患者随机分为3组:糖尿病(DM)、空腹血糖受损(IFG),与空腹血糖正常。主要预后为90天内新发卒中(缺血性或出血性)。研究者应用多变量Cox回归模型,校正潜在的协变量,评估糖调节状态和卒中风险潜在的相关性。结果:5135例患者中,糖尿病、空腹

目的:为了探讨葡萄糖调节异常是否增加轻型缺血性卒中或TIA患者新发卒中。

方法:研究者从急性非致残性脑血管事件高危患者氯吡格雷试验中获得数据,轻型卒中或TIA患者随机分为3组:糖尿病(DM)、空腹血糖受损(IFG),与空腹血糖正常。主要预后为90天内新发卒中(缺血性或出血性)。研究者应用多变量Cox回归模型,校正潜在的协变量,评估糖调节状态和卒中风险潜在的相关性。

结果:5135例患者中,糖尿病、空腹血糖受损,与正常空腹血糖的患者分别1587(30.9%),409(8%),3139(61.1%)。与正常空腹血糖相比,校正潜在协变量后,空腹血糖受损(11% vs 6.9%;aHR为 1.57,95% CI]1.13-2.19)和DM(15.8% vs 6.9%;aHR 2.38,95% CI 1.97-2.88)与轻微卒中或TIA3个月后卒中风险增加相关。研究发现空腹血糖和卒中风险之间存在J形相关,最低点为4.9 mmol/L。

结论:IFG和DM患者与轻型卒中或TIA患者卒中风险增加相关。

原始出处:

Pan Y, Jing J,et al.  Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA. Neurology. 2016. Sep 9.

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    2017-05-14 yinhl1978
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    2016-10-22 cjingjuan

    中国作者

    0

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    2016-10-11 知难而进

    继续关注!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999758, encodeId=a9bc1999e580d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun May 14 11:54:00 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720132, encodeId=86bc1e20132d6, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Mar 15 19:54:00 CST 2017, time=2017-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1747667, encodeId=28f71e4766789, content=<a href='/topic/show?id=ed7d935940d' target=_blank style='color:#2F92EE;'>#轻型卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93594, encryptionId=ed7d935940d, topicName=轻型卒中)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=002835934077, createdName=tcm111hq, createdTime=Tue Feb 07 19:54:00 CST 2017, time=2017-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=150374, encodeId=9c731503e4d6, content=中国作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c3865018, createdName=cjingjuan, createdTime=Sat Oct 22 17:37:38 CST 2016, time=2016-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145756, encodeId=5d43145e565e, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 21:53:09 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145752, encodeId=972b145e52bc, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Tue Oct 11 21:52:47 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360584, encodeId=2279136058488, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Sun Oct 09 11:54:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631783, encodeId=10c51631e83a7, content=<a href='/topic/show?id=875e2542699' target=_blank style='color:#2F92EE;'>#代谢异常#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25426, encryptionId=875e2542699, topicName=代谢异常)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c06e21824720, createdName=bettycmoon, createdTime=Sun Oct 09 11:54:00 CST 2016, time=2016-10-09, status=1, ipAttribution=)]
    2016-10-11 知难而进

    谢谢分享!

    0

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    2016-10-09 zz70
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