J Bone Oncol:胫骨远端原发性骨肿瘤的手术方案和重建策略

2018-12-26 MedSci MedSci原创

原发性恶性或侵袭性良性骨肿瘤很少发生在胫骨远端,保肢仍然是手术的主要选择。然而,在广泛肿瘤切除后的大块骨缺损的重建的方法是有争议的。该系统评价旨在评估每种重建方法的术后并发症和功能结果。检索PubMed和EMBASE数据库后,对33项研究(包括337例影响胫骨远端的肿瘤)进行了系统评价。汇总描述性统计数据,分别对不同重建方案的术后并发症和功能结果进行分析。结果显示,290名(86.1%)患者接受了

原发性恶性或侵袭性良性骨肿瘤很少发生在胫骨远端,保肢仍然是手术的主要选择。然而,在广泛肿瘤切除后的大块骨缺损的重建的方法是有争议的。该系统评价旨在评估每种重建方法的术后并发症和功能结果。

检索PubMed和EMBASE数据库后,对33项研究(包括337例影响胫骨远端的肿瘤)进行了系统评价。汇总描述性统计数据,分别对不同重建方案的术后并发症和功能结果进行分析。

结果显示,290名(86.1%)患者接受了保肢手术。重建策略包括生物重建,如自体移植,同种异体移植,牵张成骨和非生物假体置换。接受保肢手术的患者往往具有较高的MSTS评分(77.1%对70.9%,P = .055),并且局部复发率(28/290 vs 0/47,P = .052)高于截肢者。与非生物假体重建相比,生物重建方法提供了更好的功能结果(78.4%vs 72.2%,P = .017),主要并发症的发生率相似(51/253 vs 12/37,P = .091)。关于自体移植和同种异体移植重建之间的比较,自体移植术似乎有较少的主要术后并发症发生率(27/165 vs 22/78,P = .032),因此功能结果比同种异体移植重建更好(MSTS评分,80.2%对74.3%,P = .025)。

综上所述,该研究结果表明,与截肢相比,保留植体的功能结果更好。提倡生物重建,且自体移植可能被认为是更好的术后功能结果和较少的主要并发症的最佳重建方法。

原始出处:

Zhao Z, Yan T, et al., Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome. J Bone Oncol. 2018 Dec 4;14:100209. doi: 10.1016/j.jbo.2018.100209. eCollection 2019 Feb.

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    2019-04-20 apoenzyme
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    2019-09-14 minlingfeng
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    2018-12-28 yb6561