Am J Respir Crit Care Med:REM睡眠期间严重睡眠呼吸暂停可发生急性心血管事件

2018-03-26 佚名 嘉音

3月1日,在线发表于《American Journal of Respiratory and Critical Care Medicine》杂志上的一项研究显示,曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高。

3月1日,在线发表于《American Journal of Respiratory and Critical Care Medicine》杂志上的一项研究显示,曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高。

REM睡眠期间发生OSA是一个很常见的现象,10%~37%发生过OSA的患者都在REM睡眠期间出现过窒息和/或低通气现象。最近有关心脏代谢方面的研究提示REM睡眠期间出现OSA与高血压以及葡萄糖代谢损害相关。而高血压和葡萄糖代谢损害会进一步增加心血管疾病的风险。因此,本研究的目的在于明确REM睡眠特异的OSA是否会与心血管事件,如心肌梗死卒中、冠状动脉血运重建术和充血性心力衰竭相关。

本研究研究对象来自于一项前瞻性队列研究——睡眠心脏健康研究项目(Sleep Heart Health Study),包括那些患有或未患有心血管疾病的受试者,研究平均随访时间为9.5年。由于本研究的特殊性,本研究所入选的受试者均是那些非REM睡眠呼吸紊乱指数(AHI)<5次/小时的人群,最后共有3265名受试者入选。

研究结果显示,与那些REM睡眠期间AHI<5次/小时受试者(n=1758)相比,那些REM期间存在重度OSA(AHI≥30次/小时)的受试者更容易发生心血管事件(HR=1.35,95%CI:0.98~1.85)。根据受试者先前是否发生过心血管疾病分层后,分析结果显示,这一现象在那些曾经患有心血管疾病的受试者中要更为显著(HR=2.56,95%CI:1.46~4.47)。

本研究作者,巴尔的摩约翰霍普金斯大学的医学博士R.Nisha Aurora及同事认为:“先前发生心血管疾病的人群在REM睡眠期间出现的严重OSA与心血管事件高复发相关。”

原始出处:
Aurora R.N, Crainiceanu C, Gottlieb D.J, et al. Obstructive Sleep Apnea during REM Sleep and Cardiovascular Disease. Am J Respir Crit Care Med. Mar 1, 2018.

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    2018-04-14 tongyongming
  4. 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  5. 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  6. 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    2018-03-28 owlhealth

    不错耶.学习了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Mar 26 22:00:08 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299957, encodeId=69f829995e97, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Mon Mar 26 20:40:57 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299951, encodeId=f6e6299951b1, content=3月1日.在线发表于<AmericanJournalofRespiratoryandCriticalCareMedicine>杂志上的一项研究显示.曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高., 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    2018-03-27 方舒

    学习

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Mar 26 22:00:08 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299957, encodeId=69f829995e97, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Mon Mar 26 20:40:57 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299951, encodeId=f6e6299951b1, content=3月1日.在线发表于<AmericanJournalofRespiratoryandCriticalCareMedicine>杂志上的一项研究显示.曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高., 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    2018-03-26 131****2916

    不错的文章值得推荐一下

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Mar 26 22:00:08 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299957, encodeId=69f829995e97, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Mon Mar 26 20:40:57 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299951, encodeId=f6e6299951b1, content=3月1日.在线发表于<AmericanJournalofRespiratoryandCriticalCareMedicine>杂志上的一项研究显示.曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高., 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    2018-03-26 哈哈869

    学了

    0

  10. 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    2018-03-26 有备才能无患

    3月1日.在线发表于杂志上的一项研究显示.曾经发生过心血管疾病的患者如果在快速眼动(REM)睡眠期出现重度阻塞性睡眠呼吸暂停(OSA)将会使其心血管疾病复发风险进一步升高.

    0

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主要发生在REM睡眠期间的严重OSA与复合心血管终点的发病率较高有关,但仅限于心血管疾病患者。

SLEEP 2016:体重和饮食会影响不同睡眠阶段的时间

根据在SLEEP 2016年会上发表的研究结果,体重状况和蛋白质摄入量可以预测不同睡眠阶段的长度。宾夕法尼亚大学博士后研究员Andrea M. Spaeth博士和他的同事们评估了各种能量平衡参数及其对睡眠结构的影响。根据摘要,36名健康的成年人在宾夕法尼亚大学的医院的床上睡了2个连续10小时的时间,研究人员记录多导睡眠、睡眠阶段的时间、体重、身体成分、静息能量消耗、食物和饮料的摄入量等。结果表明,