J Am Acad Child:产前SSRI暴露是否影响学龄前儿童行为、情感和社会发育?

2018-03-16 MedSci MedSci原创

2018年3月,发表在《J Am Acad Child Adolesc Psychiatry》的一项由挪威科学家进行的研究,考察了妊娠期使用时间依赖的选择性5-羟色胺再摄取抑制剂(SSRI)抗抑郁药对学龄前儿童行为、情感和社会发育的影响。

2018年3月,发表在《J Am Acad Child Adolesc Psychiatry》的一项由挪威科学家进行的研究,考察了妊娠期使用时间依赖的选择性5-羟色胺再摄取抑制剂(SSRI)抗抑郁药对学龄前儿童行为、情感和社会发育的影响。

目的:旨在评估产前SSRI暴露对1.5~5岁儿童行为、情感和社会发育的影响。

方法:前瞻性挪威母亲和儿童队列研究与挪威医学出生登记相连。研究者纳入妊娠前和/或妊娠期报告抑郁/焦虑障碍的女性。妊娠早期(0~16周)、妊娠中期(17~28周)或妊娠娠晚期(>29周)使用SSRI的女性分娩出的儿童与母亲未SSRI暴露的儿童进行了比较。于1.5、3和5岁时检测了儿童的内化与外化行为(儿童行为量表)和气质特质(情感、活动和害羞的气质问卷)。研究者计算和标准化了平均评分。广义线性边际结构模型用于考虑时变暴露和混杂因素,使用了三级生长曲线模型进行审查。

结果:总共纳入了8359个母子对,其中的4128名儿童在5岁时具有完整的结局数据。与未暴露的儿童相比,暴露于妊娠晚期SSRI的儿童5岁时焦虑/抑郁行为风险增加(校正β=0.50,95% CI=0.04,0.96)。该风险在较早期暴露时不明显。无证据显示,产前SSRI对外化、社会和情感问题造成实质性影响。

结论:结果表明,产前SSRI暴露不会造成学龄前儿童外化、社会和情感问题风险大幅增加。尽管不能排除几率的作用和可能的未测量的混杂因素,但妊娠晚期SSRI暴露与后代较高的焦虑/抑郁行为相关。

原始出处:
Lupattelli A, Wood M, Ystrom E, et al.Effect of Time-Dependent Selective Serotonin Reuptake Inhibitor Antidepressants During Pregnancy on Behavioral, Emotional, and Social Development in Preschool-Aged Children.J Am Acad Child Adolesc Psychiatry. 2018 Mar;57(3):200-208. doi: 10.1016/j.jaac.2017.12.010. Epub 2017 Dec 28.

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    2018-07-06 lishizhe
  4. 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authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545470, encodeId=137915454e0cc, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616839, encodeId=fe59161683916, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-04-02 docwu2019
  5. [GetPortalCommentsPageByObjectIdResponse(id=1801486, encodeId=00b11801486d5, content=<a href='/topic/show?id=9d79e396600' target=_blank style='color:#2F92EE;'>#社会发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73966, encryptionId=9d79e396600, topicName=社会发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat May 05 08:10:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981229, encodeId=e6511981229f1, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, 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authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545470, encodeId=137915454e0cc, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616839, encodeId=fe59161683916, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-04-25 zhouqu_8
  6. [GetPortalCommentsPageByObjectIdResponse(id=1801486, encodeId=00b11801486d5, content=<a href='/topic/show?id=9d79e396600' target=_blank style='color:#2F92EE;'>#社会发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73966, encryptionId=9d79e396600, topicName=社会发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat May 05 08:10:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981229, encodeId=e6511981229f1, content=<a href='/topic/show?id=8a344564298' target=_blank style='color:#2F92EE;'>#学龄前儿童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45642, encryptionId=8a344564298, topicName=学龄前儿童)], attachment=null, authenticateStatus=null, 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CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347273, encodeId=a910134e273c4, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502524, encodeId=e8391502524ee, content=<a href='/topic/show?id=ef4b2441971' target=_blank style='color:#2F92EE;'>#产前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24419, encryptionId=ef4b2441971, topicName=产前)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545470, encodeId=137915454e0cc, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616839, encodeId=fe59161683916, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-18 neurowu
  7. 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authenticateStatus=null, createdAvatar=null, createdBy=b49a9545081, createdName=qilu_qi, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545470, encodeId=137915454e0cc, content=<a href='/topic/show?id=61d416e15a9' target=_blank style='color:#2F92EE;'>#SSRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16715, encryptionId=61d416e15a9, topicName=SSRI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1ea13741643, createdName=ms7474195563676018, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616839, encodeId=fe59161683916, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 18 05:10:00 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-18 qilu_qi
  8. 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