Int J Audiol:药物引起的听力损失的预防研究

2018-05-04 AlexYang MedSci原创

最近,有研究人员对药物诱导的耳毒性的药物干预(预防和治疗)发展的当前情况进行了回顾和研究。研究人员利用PubMed和ClinicalTrials.gov的发表文献总结了目前的科学状况。另外,研究人员提供了市场发展阶段的详细情况以及临床安全性和效果的相关证据。研究包括了44个相关的报道文献和临床或者预临床药物相关报道,这些药物已经获得了FDA试验性新药物的批准。研究发现,维生素和抗氧化物是目前最常见

最近,有研究人员对药物诱导的耳毒性的药物干预(预防和治疗)发展的当前情况进行了回顾和研究。研究人员利用PubMed和ClinicalTrials.gov的发表文献总结了目前的科学状况。另外,研究人员提供了市场发展阶段的详细情况以及临床安全性和效果的相关证据。

研究包括了44个相关的报道文献和临床或者预临床药物相关报道,这些药物已经获得了FDA试验性新药物的批准。研究发现,维生素和抗氧化物是目前最常见的用来评估药物诱导耳毒性干预的药物,这些药物可以以氧化胁迫通路为靶标,而这些氧化胁迫通路可以引起耳蜗细胞死亡和听力损失。然而,其他的策略,包括类固醇治疗和原始药物耳毒性的减弱也都进行了相关讨论。

最后,研究人员指出,在威胁生命的疾病期间和之后,听力的退化是患者接受耳毒性药物时影响他们生活治疗和家庭的重要问题。他们的研究中讨论的药物距离期望的目标还很远。他们的研究为听力供应商询问患者的选择和相关的跨学科护理团队提供了基础知识。

原始出处:

Hammill TL, Campbell KC. Protection for medication-induced hearing loss: the state of the science. Int J Audiol. 24 April 2018.

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    2018-05-11 沙漠浪人

    听力损失预防

    0

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    2018-05-06 docwu2019
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    2018-05-06 张新亮1853311252142e2fm

    好文献学习了

    0

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    2018-05-05 zdvfsadb

    学习了

    0

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    2018-05-05 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-05-05 1e0f8808m18(暂无匿称)

    预防药物性耳聋很重要.

    0

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