J Cell Physiol:研究揭示miR-6869-5在结直肠癌发生发展中的作用机制

2017-12-09 MedSci MedSci原创

许多研究表明microRNAs(miRNAs)作为非编码RNA在结直肠癌(CRC)的发展和进展中发挥重要作用。然而,对于新发现的miRNA(miR-6869-5p)在CRC中的作用知之甚少。本研究旨在探究miR-6869-5在结直肠癌发生和发展中的修饰作用及其机制。收集来自CRC患者的血清外泌体及肿瘤组织样本,结果均可发现miR-6869-5p的水平明显降低。使用targetscan数据库预测mi

许多研究表明microRNAs(miRNAs)作为非编码RNA在结直肠癌(CRC)的发展和进展中发挥重要作用。然而,对于新发现的miRNA(miR-6869-5p)在CRC中的作用知之甚少。本研究旨在探究miR-6869-5在结直肠癌发生和发展中的修饰作用及其机制。

收集来自CRC患者的血清外泌体及肿瘤组织样本,结果均可发现miR-6869-5p的水平明显降低。使用targetscan数据库预测miR-6869-5p的靶目标,ORG和miRDBA数据库显示miR-6869-5p的潜在靶标为toll样受体4(TLR4)。MiR-6869-5p通过直接靶向TLR4可抑制CRC细胞的增殖和炎性细胞因子(TNF-α和IL-6)的产生。miR-6869-5p在结直肠癌变过程中的保护作用依赖于TLR4/NF-κB信号通路。另外,3年存活率较差的CRC患者,其血清外泌体中miR-6869-5p的水平较低。

综上所述,该研究结果表明,miR-6869-5p或可作为结直肠癌的肿瘤抑制因子,而血清外泌体miR-6869-5p是预测CRC患者预后的一种有用的循环生物标志物。

原始出处:

Yan S, Wang Z, et al., MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-κB signaling pathway in colorectal cancer. J Cell Physiol. 2017 Dec 5. doi: 10.1002/jcp.26316.

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    2018-08-18 维他命
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    2018-09-05 smallant2002
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    2017-12-09 zt123

    边走边走边伯贤不在身边

    0