Clin Chem:循环肿瘤细胞作为复发或转移性头颈部鳞状细胞癌的预后因素?

2019-10-23 MedSci MedSci原创

本前瞻性多中心研究评估了循环肿瘤细胞(CTCs)在复发、非手术或转移性头颈鳞癌(rHNSCC)化疗和西妥昔单抗治疗中的预后价值。

本前瞻性多中心研究评估了循环肿瘤细胞(CTCs)在复发、非手术或转移性头颈鳞癌(rHNSCC)化疗和西妥昔单抗治疗中的预后价值。

研究人员对65例适合分析的患者分别于治疗第0(D0)、第7天、第21天取外周血,采用CellSearch®EPISPOT、流式细胞术(FCM)检测CTC。采用Kaplan-Meier法评估PFS,并与log-rank检验比较(P < 0.05)

研究发现,在D0时,使用EPISPOTCellSearchFCM可分别检测出69%(45/65)21%(12/58)11%(7/61)ctc。在所有3种方法检测的患者中,EPISPOT分别在D0D7D21的阳性样本中识别92%(36/39)92%(35/38)90%(25/28)。在(a) CTC计数从D0增加到D7EPISPOTEGFR稳定(36/54)的患者(3.9个月vs 6.2个月;95%置信区间,5.0 - -6.9;P = 0.0103)(b)使用EPISPOTCellSearch®(37/51)(P = 0.0311)EPISPOTFCM (38/54) (P = 0.0480)CellSearchFCM (11/51) (P = 0.0005)检测≥1 CTC的患者(P = 0.0103)PFS中位数时间显著较低。

研究表明,rHNSCC患者化疗前后均可检测到CTCs。用EPISPOTEGFR评价的D0-D7 CTC动力学与治疗反应相关。本研究提示CTCs可作为实时液体活检来监测rHNSCC早期化疗反应。

原始出处:

Renaud Garrel, Martine Mazel,Circulating Tumor Cells as a Prognostic Factor in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: The CIRCUTEC Prospective Study

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    2019-10-25 wshxjq
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