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Mater Sci Eng C Mater Biol Appl：3D打印多功能PLA-胶原蛋白 - 米诺环素 - 纳米羟基磷灰石支架可有效发挥抗菌成骨的作用

2019-04-29 不详 网络

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3D打印和增材制造可以是设计定制结构的强大技术，并且制备具有适合骨修复的多功能效果的合成骨移植物。本研究中，我们旨在开发具有生物启发表面涂层的新型多功能3D打印聚（乳酸）（PLA）支架，其能够减少细菌生物膜形成，同时有利于人骨髓来源的间充质干细胞（hMSC）活性。为此，研究人员使用3D打印制备PLA支架，并进一步使用胶原（Col），米诺环素（MH）和生物诱导的柠檬酸盐-羟基磷灰石纳米颗粒（cHA）

3D打印和增材制造可以是设计定制结构的强大技术，并且制备具有适合骨修复的多功能效果的合成骨移植物。本研究中，我们旨在开发具有生物启发表面涂层的新型多功能3D打印聚（乳酸）（PLA）支架，其能够减少细菌生物膜形成，同时有利于人骨髓来源的间充质干细胞（hMSC）活性。

为此，研究人员使用3D打印制备PLA支架，并进一步使用胶原（Col），米诺环素（MH）和生物诱导的柠檬酸盐-羟基磷灰石纳米颗粒（cHA）进行多功能化。PLA-Col-MH-cHA支架提供了接近天然骨结构的更紧密的结构支撑，具有均匀的大孔，足够的润湿性和优异的抗压强度。添加MH导致足够的抗生素释放特征，对金黄色葡萄球菌具有抗菌活性。此外，cHA的掺入明显刺激了hMSCs的粘附，增殖和成骨相关的基因表达（RUNX2，OCN和OPN）。

总之，该研究结果表明这种3D打印的PLA-Col-MH-cHA支架的适用性，可用于将来在骨修复中的应用。通过针对骨修复，同时减轻与骨植入物相关的典型感染，我们的3D支架提供了综合策略，其综合效果进一步设想了骨植入装置成功率的提高。

原始出处：

Martin V, Ribeiro IA, et al., Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration. Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:15-26. doi: 10.1016/j.msec.2019.03.056. Epub 2019 Mar 19.

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    2019-05-13 12498ebem31暂无昵称

    #Biol#

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    2019-07-15 spoonycyy

    #Eng#

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    2020-02-03 sunylz

    #Bio#

    0

  4. 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createdBy=3516494, createdName=spoonycyy, createdTime=Mon Jul 15 14:53:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918660, encodeId=cbaa19186605f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Feb 03 14:53:00 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079952, encodeId=39d920e99520b, content=<a href='/topic/show?id=225ce7444df' target=_blank style='color:#2F92EE;'>#纳米羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77444, encryptionId=225ce7444df, topicName=纳米羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Fri Jan 17 11:53:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330809, encodeId=6839133080998, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336118, encodeId=148f13361187e, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352115, encodeId=c68b135211547, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441211, encodeId=1532144121126, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485717, encodeId=17c61485e17f1, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2020-01-17 dinorsor524

    #纳米羟基磷灰石#

    0

  5. 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encryptionId=225ce7444df, topicName=纳米羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Fri Jan 17 11:53:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330809, encodeId=6839133080998, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336118, encodeId=148f13361187e, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352115, encodeId=c68b135211547, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441211, encodeId=1532144121126, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485717, encodeId=17c61485e17f1, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2019-05-01 ms7899726347904398

    #抗菌#

    0

  6. 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encryptionId=225ce7444df, topicName=纳米羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Fri Jan 17 11:53:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330809, encodeId=6839133080998, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336118, encodeId=148f13361187e, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352115, encodeId=c68b135211547, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441211, encodeId=1532144121126, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485717, encodeId=17c61485e17f1, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2019-05-01 ms9833124466084992

    #3D#

    0

  7. 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encryptionId=225ce7444df, topicName=纳米羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Fri Jan 17 11:53:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330809, encodeId=6839133080998, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336118, encodeId=148f13361187e, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352115, encodeId=c68b135211547, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441211, encodeId=1532144121126, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485717, encodeId=17c61485e17f1, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, 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    2019-05-01 zhaojie88

    #成骨#

    0

  8. 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topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2019-05-01 ms5880526374914242

    #米诺环素#

    0

  9. 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topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2019-05-01 12498e5fm14(暂无昵称)

    #胶原蛋白#

    0

  10. 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encryptionId=225ce7444df, topicName=纳米羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Fri Jan 17 11:53:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330809, encodeId=6839133080998, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336118, encodeId=148f13361187e, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352115, encodeId=c68b135211547, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441211, encodeId=1532144121126, content=<a href='/topic/show?id=0172e6110bf' target=_blank style='color:#2F92EE;'>#米诺环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76110, encryptionId=0172e6110bf, topicName=米诺环素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=12284802660, createdName=ms5880526374914242, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485717, encodeId=17c61485e17f1, content=<a href='/topic/show?id=8f0c840392a' target=_blank style='color:#2F92EE;'>#胶原蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84039, encryptionId=8f0c840392a, topicName=胶原蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc8038511, createdName=12498e5fm14(暂无昵称), createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622160, encodeId=22c216221602f, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed May 01 08:53:00 CST 2019, time=2019-05-01, status=1, ipAttribution=)]
    2019-05-01 爆笑小医

    #羟基磷灰石#

    0

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