Eur Respir J:产前接触抗生素与儿童哮喘

2018-07-06 xing.T MedSci原创

由此可见,产前接触抗生素与哮喘风险的剂量依赖性增加有关。然而,在妊娠前后产妇接触抗生素都观察到了类似关联,这些结果表明这种关联要么不是直接因果关系,要么不是妊娠特异性。

婴儿期抗生素的使用会改变肠道微生物群和免疫发育,并增加儿童哮喘的风险。产前接触抗生素儿童哮喘的影响尚不清楚。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员试图描述产前接触抗生素与儿童哮喘之间的关联。

研究人员使用来自于加拿大曼尼托巴省在1996年至2012年间出生的213661名母子的处方记录、住院记录和医生账单索赔进行了一项基于人群的队列研究。调整产妇哮喘、产后抗生素和其他潜在的混杂因素后,研究人员使用Cox回归确定这种关联。敏感性分析评估了妊娠前、后产妇抗生素的使用情况。

36.8%的儿童在产前接触抗生素,10.1%的儿童发生哮喘。产前接触抗生素与哮喘风险增加有关(校正风险比(aHR)为1.23,95%CI为1.20-1.27)。存在明显的剂量反应(一个疗程aHR为1.15,95%CI为1.11-1.18;两个疗程aHR为1.26,95%CI为1.21-1.32;三个或更多疗程aHR为1.51,95%CI为1.44-1.59)。妊娠前9个月(aHR为1.27,95%CI为1.24-1.31)和产后9个月(aHR为1.32,95%CI为1.28-1.36)母体服用抗生素与哮喘具有相似的相关性。

由此可见,产前接触抗生素与哮喘风险的剂量依赖性增加有关。然而,在妊娠前后产妇接触抗生素都观察到了类似关联,这些结果表明这种关联要么不是直接因果关系,要么不是妊娠特异性。

原始出处:

Keely Loewen,et al. Prenatal antibiotic exposure and childhood asthma: a population-based study. Eur Respir J. 2018. http://erj.ersjournals.com/content/52/1/1702070

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    2018-07-08 qilu_qi
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    2018-07-07 龙胆草

    学习谢谢分享

    0

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    2018-07-06 清风拂面

    谢谢分享学习

    0

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